Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 4/20 | 0.45 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP24A1 | Q07973 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9728217 | 0.92 | CYP17A1 (0.45) | CYP26A1CYP17A1PKML3MBTL1NPC1 | |
| SCHEMBL9196029 | 0.84 | L3MBTL1 (0.51) | CYP26A1CYP17A1PKML3MBTL1NPC1 | |
| SCHEMBL10581631 | 0.84 | MAPT (0.48) | CYP26A1CYP17A1PKML3MBTL1MAPT | |
| SCHEMBL9190598 | 0.84 | CYP26A1 (0.44) | CYP26A1CYP17A1PKML3MBTL1NPC1 | |
| SCHEMBL10581927 | 0.84 | MAPT (0.48) | CYP26A1CYP17A1PKMCYP19A1MAPT | |
| SCHEMBL9728182 | 0.79 | CYP19A1 (0.59) | PKML3MBTL1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL10580748 | 0.79 | CYP19A1 (0.48) | CYP26A1CYP17A1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL10580653 | 0.77 | CYP19A1 (0.51) | CYP26A1CYP17A1PKMCYP11B1CYP11B2 | |
| SCHEMBL9664929 | 0.76 | CYP19A1 (0.45) | CYP26A1CYP17A1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL9191000 | 0.76 | CYP17A1 (0.44) | CYP26A1CYP17A1NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5151421-A | Compounds for inhibition of metabolism of retinoids, for treatment for proliferation of epithelial cells and keratin disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-29 | — | — | US | disclosed |
| US-5028606-A | Retinoid metabolism inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-07-02 | — | — | US | disclosed |