Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 9/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | QPCT | Q16769 | 1/20 | 0.46 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.46 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.46 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9194729 | 0.84 | CYP19A1 (0.63) | CYP19A1ALDH1A1LMNASMN1; SMN2TBXAS1 | |
| SCHEMBL10581180 | 0.84 | ALDH1A1 (0.61) | CYP19A1ALDH1A1LMNASMN1; SMN2CYP11B1 | |
| SCHEMBL10580633 | 0.83 | CYP19A1 (0.58) | CYP19A1ALDH1A1LMNASMN1; SMN2CYP11B1 | |
| SCHEMBL27293916 | 0.81 | ALDH1A1 (0.58) | CYP19A1ALDH1A1LMNASMN1; SMN2CYP11B1 | |
| SCHEMBL9728652 | 0.81 | CYP19A1 (0.41) | CYP19A1CYP3A4MAPTPKML3MBTL1 | |
| SCHEMBL9728310 | 0.79 | CYP26A1 (0.45) | CYP19A1ALDH1A1CYP11B1CYP11B2MAPT | |
| SCHEMBL10579958 | 0.79 | ALDH1A1 (0.67) | CYP19A1ALDH1A1LMNASMN1; SMN2CYP11B1 | |
| SCHEMBL9728217 | 0.77 | CYP17A1 (0.45) | CYP11B1CYP11B2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10578330 | 0.77 | CYP19A1 (0.61) | CYP19A1ALDH1A1LMNASMN1; SMN2CYP11B1 | |
| SCHEMBL10582020 | 0.76 | MAPT (0.55) | CYP19A1ALDH1A1LMNASMN1; SMN2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5151421-A | Compounds for inhibition of metabolism of retinoids, for treatment for proliferation of epithelial cells and keratin disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-29 | — | — | US | disclosed |
| US-5028606-A | Retinoid metabolism inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-07-02 | — | — | US | disclosed |