Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.61 |
| ▸ | RAB9A | P51151 | 6/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | RECQL | P46063 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2615402 | 0.83 | GAA (0.65) | GAARAB9AKDM4EPOLBHTT | |
| SCHEMBL1764515 | 0.80 | RAB9A (0.64) | GAARAB9AKDM4EPOLBHTT | |
| SCHEMBL225793 | 0.80 | RECQL (0.64) | GAARAB9AKDM4EPOLBHTT | |
| SCHEMBL2405184 | 0.80 | RAB9A (0.71) | GAARAB9AKDM4EPOLBHTT | |
| SCHEMBL1434288 | 0.80 | GAA (0.66) | GAARAB9AKDM4EPOLBHTT | |
| SCHEMBL1764592 | 0.80 | RAB9A (0.61) | GAARAB9AKDM4EPOLBHTT | |
| SCHEMBL9528793 | 0.80 | KDM4E (0.63) | GAARAB9AKDM4EPOLBHTT | |
| SCHEMBL17790891 | 0.80 | GAA (0.61) | GAARAB9AKDM4EPOLBHTT | |
| SCHEMBL155616 | 0.79 | RECQL (0.62) | GAARAB9AKDM4EPOLBHTT | |
| SCHEMBL9571659 | 0.79 | KDM4E (0.59) | GAARAB9AKDM4EPOLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5164388-A | Hypotensive agents, treatment of congestive heart failure | ABBOTT LABORATORIES (US) | 1992-11-17 | — | — | US | disclosed |
| EP-0439556-A4 | HETEROCYCLIC PEPTIDE RENIN INHIBITORS | — | 1991-10-30 | — | — | EP | disclosed |