SCHEMBL1434288

SCHEMBL1434288

Cc1nc(-c2ccc(O)cc2)cs1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 5/20 0.66
KDM4E B2RXH2 3/20 0.66
POLB P06746 3/20 0.66
MAPT P10636 3/20 0.66
HPGD P15428 3/20 0.66
ALDH1A1 P00352 3/20 0.66
RECQL P46063 2/20 0.66
ESR2 Q92731 1/20 0.66
LTA4H P09960 1/20 0.63
MKNK1 Q9BUB5 1/20 0.63
MKNK2 Q9HBH9 1/20 0.63
RAB9A P51151 3/20 0.62
HTT P42858 2/20 0.62
GFER P55789 1/20 0.57
AMY1A P0DUB6 2/20 0.55
ALOX5 P09917 1/20 0.55
SMN1; SMN2 Q16637 2/20 0.54
USP2 O75604 1/20 0.54
LMNA P02545 1/20 0.54
THRB P10828 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL8050945 0.98 GAA (0.65) GAAKDM4EPOLBMAPTHPGD
SCHEMBL2615402 0.83 GAA (0.65) GAAKDM4EPOLBMAPTHPGD
SCHEMBL225793 0.80 RECQL (0.64) GAAKDM4EPOLBMAPTHPGD
SCHEMBL9528793 0.80 KDM4E (0.63) GAAKDM4EPOLBMAPTHPGD
SCHEMBL9728319 0.80 GAA (0.61) GAAKDM4EPOLBMAPTHPGD
SCHEMBL1764515 0.80 RAB9A (0.64) GAAKDM4EPOLBMAPTHPGD
SCHEMBL17790891 0.80 GAA (0.61) GAAKDM4EPOLBMAPTHPGD
SCHEMBL2405184 0.80 RAB9A (0.71) GAAKDM4EPOLBMAPTHPGD
SCHEMBL1764592 0.80 RAB9A (0.61) GAAKDM4EPOLBMAPTHPGD
SCHEMBL12282347 0.79 LTA4H (0.58) GAAKDM4EPOLBMAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015183931-A1 STABILIZED CHEMILUMINESCENT SYSTEM LI-COR, INC. (US) 2015-12-03 WO claimed
US-20150346202-A1 STABILIZED CHEMILUMINESCENT SYSTEM Ll-COR, INC. (US) 2015-12-03 US claimed
EP-0384271-B1 Method for enhancement of chemiluminescence WAKO PURE CHEM IND LTD (JP) 1996-05-08 EP claimed
US-5106732-A Using oxazole or thiazole derivative TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1992-04-21 US claimed
EP-0384271-A2 Method for enhancement of chemiluminescence WAKO PURE CHEMICAL INDUSTRIES LTD (JP) 1990-08-29 EP claimed
CN-105315319-B Hepatitis C virus inhibitor and application thereof 南京圣和药业股份有限公司 2020-11-20 CN disclosed
EP-2694472-B1 SULFONAMIDE DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2020-03-11 EP disclosed
US-9597310-B2 Indanyloxydihydrobenzofuranylacetic acids BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2017-03-21 US disclosed
US-9527807-B2 Sulfonamide derivative and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-12-27 US disclosed
EP-2928886-B1 NEW INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS BOEHRINGER INGELHEIM INT (DE) 2016-11-02 EP disclosed
US-20160235706-A1 INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2016-08-18 US disclosed
US-20150346202-A1 STABILIZED CHEMILUMINESCENT SYSTEM Ll-COR, INC. (US) 2015-12-03 US disclosed
EP-1193250-A1 PHENYL SULFAMATE DERIVATIVES Teikoku Hormone Mfg. Co., Ltd. (JP) 2002-04-03 EP disclosed
US-5051437-A Treatment of rhinovirus or picornaviruses STERLING DRUG INC. (US) 1991-09-24 US disclosed
US-4857539-A Heterocyclic substituted-phenoxyalkylisoxazoles as antiviral useful agents STERLING DRUG INC. (US) 1989-08-15 US disclosed
US-4533550-A FUNGICIDES, BACTERICIDES JANSSEN PHARMACEUTICA, N.V. (BE) 1985-08-06 US disclosed
EP-0006712-B1 HETEROCYCLIC DERIVATIVES OF (4-ARYLOXYMETHYL-1.3-DIOXOLAN-2-YL) METHYL-1H-IMIDAZOLES AND -1H-1.2.4-TRIAZOLES, THEIR PREPARATION AND THE DERIVATIVES FOR USE AS FUNGICIDES AND BACTERICIDES JANSSEN PHARMACEUTICA N.V. (BE) 1983-11-30 EP disclosed
US-4313953-A BACTERICIDES, FUNGICIDES JANSSEN PHARMACEUTICA, N.V. (BE) 1982-02-02 US disclosed
US-4218458-A FUNGICIDES, BACTERICIDES JANSSEN PHARMACEUTICA, N.V. (BE) 1980-08-19 US disclosed
EP-0006712-A1 Heterocyclic derivatives of (4-aryloxymethyl-1.3-dioxolan-2-yl) methyl-1H-imidazoles and -1H-1.2.4-triazoles, their preparation and the derivatives for use as fungicides and bactericides JANSSEN PHARMACEUTICA N.V. (BE) 1980-01-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160235706-A1 INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS GPR119, GPBAR1, GPR52 GAA 1426/4885KDM4E 3625/4885POLB 4765/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.