Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | GAA | P10253 | 4/20 | 0.55 |
| ▸ | GLA | P06280 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | RAD52 | P43351 | 2/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TTR | P02766 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9616809 | 0.78 | ALDH1A1 (0.56) | KDM4EMAPK1ALDH1A1GAAGLA | |
| SCHEMBL12199181 | 0.76 | KDM4E (1.00) | KDM4EMAPK1ALDH1A1GAAGLA | |
| Diethylamine SCHEMBL9616787 | 0.76 | APP (0.47) | KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL9616705 | 0.76 | TOP2A (0.56) | KDM4EGAAGLAPOLBRAB9A | |
| SCHEMBL31582428 | 0.74 | ALDH1A1 (0.63) | KDM4EMAPK1ALDH1A1GAAGLA | |
| SCHEMBL2323024 | 0.74 | ALDH1A1 (0.63) | KDM4EMAPK1ALDH1A1GAAGLA | |
| SCHEMBL13367213 | 0.74 | HDAC1 (0.39) | — | |
| SCHEMBL24038284 | 0.73 | APP (0.70) | KDM4EMAPK1ALDH1A1GAAGLA | |
| SCHEMBL12058552 | 0.72 | ELANE (0.39) | KDM4EALDH1A1GAAHPGDL3MBTL1 | |
| SCHEMBL11340503 | 0.71 | ALDH1A1 (0.49) | KDM4EMAPK1ALDH1A1GAAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0478545-A1 | 1,2,4-BENZOTRIAZINE OXIDES AS RADIOSENSITIZERS AND SELECTIVE CYTOTOXIC AGENTS | SRI INTERNATIONAL (US) | 1992-04-08 | — | — | EP | disclosed |
| WO-1991004028-A1 | 1,2,4-BENZOTRIAZINE OXIDES AS RADIOSENSITIZERS AND SELECTIVE CYTOTOXIC AGENTS | SRI INTERNATIONAL (US) | 1991-04-04 | — | — | WO | disclosed |