SCHEMBL9728675

SCHEMBL9728675

Cc1ncnc(NC(C)c2ccc(Oc3c(F)c(F)c(F)c(F)c3F)cc2)c1Cl

nearest known ligand 0.39

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
EGFR P00533 13/20 0.39
CNR1 P21554 1/20 0.35
CNR2 P34972 1/20 0.35
GALR3 O60755 1/20 0.35
NR2F2 P24468 1/20 0.35
IDH1 O75874 1/20 0.35
PIK3CA P42336 1/20 0.34
P2RX3 P56373 2/20 0.34
NTRK1 P04629 1/20 0.34
KRAS P01116 1/20 0.33
SOS1 Q07889 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9729816 0.89 EGFR (0.40) EGFRGALR3NR2F2IDH1P2RX3
SCHEMBL9729031 0.85 EGFR (0.36) EGFR
SCHEMBL9728933 0.85 IDH1 (0.37) EGFRCNR1CNR2GALR3NR2F2
SCHEMBL15684923 0.82 CNR1 (0.51) EGFRCNR1CNR2GALR3NR2F2
SCHEMBL11108087 0.82 EGFR (0.47) EGFRGALR3NR2F2IDH1P2RX3
SCHEMBL9728970 0.81 EGFR (0.40) EGFRCNR1CNR2GALR3NR2F2
SCHEMBL11099038 0.79 EGFR (0.45) EGFRCNR1CNR2GALR3NR2F2
SCHEMBL11102122 0.79 CNR1 (0.47) EGFRCNR1CNR2GALR3NR2F2
SCHEMBL9729004 0.79 IDH1 (0.39) EGFRGALR3NR2F2IDH1KRAS
SCHEMBL15684818 0.77 NTRK1 (0.36) EGFRCNR1CNR2GALR3NR2F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5141941-A ARALKYLAMINE DERIVATIVES, AND FUNGICIDES CONTAINING THE SAME UBE INDUSTRIES, LTD. (JP) 1992-08-25 US claimed