SCHEMBL9728933

SCHEMBL9728933

CCc1ncnc(NC(C)c2ccc(Oc3c(F)c(F)c(F)c(F)c3F)cc2)c1Cl

nearest known ligand 0.37

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
IDH1 O75874 1/20 0.37
EGFR P00533 12/20 0.37
ACACB O00763 1/20 0.34
CNR1 P21554 1/20 0.34
CNR2 P34972 1/20 0.34
CRHR1 P34998 1/20 0.33
GALR3 O60755 1/20 0.33
NR2F2 P24468 1/20 0.33
HTR7 P34969 1/20 0.33
ERBB2 P04626 1/20 0.33
KDR P35968 1/20 0.33
KRAS P01116 1/20 0.32
SOS1 Q07889 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9729004 0.90 IDH1 (0.39) IDH1EGFRCRHR1GALR3NR2F2
SCHEMBL9212072 0.88 EGFR (0.36) EGFRACACBCRHR1
SCHEMBL9728675 0.85 EGFR (0.39) IDH1EGFRCNR1CNR2GALR3
SCHEMBL15684929 0.83 CNR1 (0.48) IDH1EGFRACACBCNR1CNR2
SCHEMBL9729823 0.83 EGFR (0.39) IDH1EGFRACACBCNR1CNR2
SCHEMBL9212840 0.81 ALDH1A1 (0.35) EGFRCRHR1
SCHEMBL9208274 0.80 PIK3CD (0.34) EGFRCRHR1
SCHEMBL17087733 0.80 KDM4E (0.39) ACACBCRHR1
SCHEMBL9729816 0.79 EGFR (0.40) IDH1EGFRGALR3NR2F2KRAS
SCHEMBL15684926 0.79 LMNA (0.43) CNR1CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5141941-A ARALKYLAMINE DERIVATIVES, AND FUNGICIDES CONTAINING THE SAME UBE INDUSTRIES, LTD. (JP) 1992-08-25 US claimed