Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 10/20 | 0.69 |
| ▸ | PIM1 | P11309 | 10/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.52 |
| ▸ | CDK2 | P24941 | 3/20 | 0.52 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.52 |
| ▸ | BRAF | P15056 | 5/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11480970 | 0.87 | BRAF (0.54) | NTRK1PIM1KDM4EACVR1CHEK1 | |
| SCHEMBL9728647 | 0.82 | KDM4E (0.48) | NTRK1PIM1KDM4EACVR1CHEK1 | |
| SCHEMBL9878320 | 0.82 | KDM4E (0.48) | NTRK1PIM1KDM4EACVR1CHEK1 | |
| SCHEMBL3171563 | 0.80 | KDM4E (0.54) | NTRK1PIM1KDM4ECDK2BRAF | |
| SCHEMBL11474283 | 0.78 | KDM4E (0.60) | NTRK1PIM1KDM4ECDK2BRAF | |
| SCHEMBL11472391 | 0.78 | NTRK1 (0.68) | NTRK1PIM1KDM4EACVR1CDK2 | |
| SCHEMBL9728870 | 0.78 | NTRK1 (0.65) | NTRK1PIM1KDM4EACVR1CHEK1 | |
| SCHEMBL8435070 | 0.78 | KDM4E (1.00) | KDM4EBRAFTLR8 | |
| SCHEMBL11465926 | 0.78 | BRAF (0.56) | KDM4EBRAF | |
| SCHEMBL11465978 | 0.77 | KDM4E (0.52) | NTRK1PIM1KDM4ECDK2BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5169850-A | Neurotropic or hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1992-12-08 | — | — | US | disclosed |
| US-5059691-A | Anxiolytic agents; hypotensive agents; nervous system disorders; cognition activators | AMERICAN CYANAMID COMPANY (US) | 1991-10-22 | — | — | US | disclosed |