Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 10/20 | 0.65 |
| ▸ | PIM1 | P11309 | 10/20 | 0.65 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.57 |
| ▸ | CDK2 | P24941 | 4/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.39 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.38 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9877259 | 0.81 | NTRK1 (0.43) | NTRK1PIM1ACVR1CDK2CHEK1 | |
| SCHEMBL9728862 | 0.78 | NTRK1 (0.69) | NTRK1PIM1ACVR1CDK2CHEK1 | |
| SCHEMBL4307227 | 0.76 | KMO (0.47) | CDK2SCN9ASCN10AKMOCDC7 | |
| SCHEMBL9728834 | 0.74 | NTRK1 (0.71) | NTRK1PIM1ACVR1CDK2CHEK1 | |
| SCHEMBL11461808 | 0.73 | KMO (0.41) | CDK2SCN9ASCN10AKMOCDC7 | |
| SCHEMBL4307223 | 0.72 | CDC7 (0.48) | CDK2SCN9ASCN10AKMOCDC7 | |
| SCHEMBL27707931 | 0.71 | SCN9A (0.44) | CDK2MAPTSCN9ASCN10ACDC7 | |
| SCHEMBL31277907 | 0.70 | NTRK1 (0.65) | NTRK1PIM1ACVR1CDK2CHEK1 | |
| SCHEMBL11465849 | 0.70 | BRAF (0.59) | MAPTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL10941762 | 0.68 | MAP2K1 (0.49) | PIM1KMOKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5169850-A | Neurotropic or hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1992-12-08 | — | — | US | disclosed |
| US-5059691-A | Anxiolytic agents; hypotensive agents; nervous system disorders; cognition activators | AMERICAN CYANAMID COMPANY (US) | 1991-10-22 | — | — | US | disclosed |