Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9729219 | 1.00 | PPARA (0.51) | PPARAKCNH2NOS2TLR8ALDH1A1 | |
| SCHEMBL9729101 | 1.00 | PPARA (0.51) | PPARAKCNH2NOS2TLR8ALDH1A1 | |
| SCHEMBL9730031 | 1.00 | PPARA (0.51) | PPARAKCNH2NOS2TLR8ALDH1A1 | |
| SCHEMBL9728758 | 1.00 | PPARA (0.51) | PPARAKCNH2NOS2TLR8ALDH1A1 | |
| SCHEMBL1578164 | 0.98 | PPARA (0.49) | PPARAKCNH2NOS2TLR8ALDH1A1 | |
| SCHEMBL27773876 | 0.92 | NOS2 (0.46) | PPARAKCNH2NOS2TLR8 | |
| SCHEMBL9107721 | 0.84 | — | — | |
| SCHEMBL7504627 | 0.81 | PPARA (0.54) | PPARAKCNH2NOS2ALDH1A1GPR84 | |
| SCHEMBL25970261 | 0.81 | PPARA (0.54) | PPARAKCNH2NOS2ALDH1A1GPR84 | |
| SCHEMBL24411607 | 0.79 | NOS2 (0.46) | PPARANOS2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5162360-A | Treating hypercholesterolemia and atherosclerosis; ACAT acyl-coenzyme A:-cholesterol acyltransferase | WARNER-LAMBERT COMPANY (US) | 1992-11-10 | — | — | US | disclosed |