Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.42 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.42 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.42 |
| ▸ | CBFB | Q13951 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TERT | O14746 | 2/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13415774 | 0.76 | ALDH1A1 (0.47) | KDM4EMEN1MAPTKMT2ANPC1 | |
| SCHEMBL15447473 | 0.73 | BACE1 (0.48) | NPC1RAB9AMGAMALDH1A1HDAC8 | |
| SCHEMBL26802086 | 0.73 | CYP1A2 (0.55) | KDM4EMEN1MAPTKMT2ANPC1 | |
| SCHEMBL13843590 | 0.73 | HSD17B14 (0.54) | KDM4EMEN1MAPTKMT2AGLA | |
| SCHEMBL262639 | 0.71 | BACE1 (0.50) | NPC1RAB9AALDH1A1HDAC8MAOA | |
| SCHEMBL12520746 | 0.71 | MGAM (0.38) | KDM4EMEN1MAPTKMT2ANPC1 | |
| SCHEMBL12849492 | 0.70 | CNR2 (0.51) | KDM4EMEN1MAPTKMT2ANPC1 | |
| SCHEMBL12405037 | 0.70 | MGAM (0.63) | KDM4EMEN1MAPTKMT2ARAB9A | |
| SCHEMBL29484746 | 0.69 | MGAM (0.68) | KDM4EMEN1MAPTKMT2ANPC1 | |
| SCHEMBL29484748 | 0.69 | MGAM (0.68) | KDM4EMEN1MAPTKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1016872-B | BCD TRICYCLIC ERGOLINE PART-STRUCTURE ANALOGUSE | LILLY CO ELI (US) | 1992-06-03 | — | — | CN | claimed |
| EP-0250179-A2 | BCD tricyclic ergoline part-structure analogues | ELI LILLY AND COMPANY (US) | 1987-12-23 | — | — | EP | claimed |
| US-5134143-A | Dopamine Agonists | ELI LILLY AND COMPANY (US) | 1992-07-28 | — | — | US | disclosed |
| CN-1016872-B | BCD TRICYCLIC ERGOLINE PART-STRUCTURE ANALOGUSE | LILLY CO ELI (US) | 1992-06-03 | — | — | CN | disclosed |
| US-4977160-A | DOPAMINE AGONISTS; PARKINSON*S DISEASE | ELI LILLY AND COMPANY (US) | 1990-12-11 | — | — | US | disclosed |
| US-4826986-A | DOPAMINE AGONISTS | ELI LILLY AND COMPANY (US) | 1989-05-02 | — | — | US | disclosed |
| CN-87104651-A | The BCD tricyclic ergoline part-structure analoguse | — | 1988-01-13 | — | — | CN | disclosed |
| EP-0250179-A2 | BCD tricyclic ergoline part-structure analogues | ELI LILLY AND COMPANY (US) | 1987-12-23 | — | — | EP | disclosed |