Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.49 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | GCK | P35557 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9729377 | 0.83 | NPC1 (0.63) | RAB9ANPC1MAPTSMN1; SMN2LMNA | |
| SCHEMBL9729076 | 0.82 | MAPT (0.64) | RAB9AMAPTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL10816647 | 0.81 | RAB9A (0.71) | RAB9ANPC1MAPTSMN1; SMN2LMNA | |
| SCHEMBL462304 | 0.79 | LPAR1 (0.66) | SMN1; SMN2LMNAMEN1KMT2ALPAR1 | |
| SCHEMBL9729953 | 0.78 | — | — | |
| SCHEMBL9728949 | 0.78 | — | — | |
| SCHEMBL18236206 | 0.76 | RAB9A (0.74) | RAB9ANPC1MAPTSMN1; SMN2LMNA | |
| SCHEMBL10798732 | 0.73 | MAPT (0.62) | RAB9ANPC1MAPTSMN1; SMN2LMNA | |
| SCHEMBL9723517 | 0.72 | KMT2A (0.61) | SMN1; SMN2LMNAMEN1KMT2ALPAR1 | |
| SCHEMBL4919310 | 0.72 | MAPT (1.00) | RAB9ANPC1MAPTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5162360-A | Treating hypercholesterolemia and atherosclerosis; ACAT acyl-coenzyme A:-cholesterol acyltransferase | WARNER-LAMBERT COMPANY (US) | 1992-11-10 | — | — | US | disclosed |