Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.63 |
| ▸ | RAB9A | P51151 | 6/20 | 0.63 |
| ▸ | MEN1 | O00255 | 5/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | CCR4 | P51679 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.50 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.50 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9729172 | 0.83 | RAB9A (0.56) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL20788543 | 0.82 | NPC1 (0.77) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL9729076 | 0.79 | MAPT (0.64) | RAB9AMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL10078890 | 0.78 | NPC1 (0.63) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL10078887 | 0.78 | MEN1 (1.00) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL77497 | 0.77 | NPC1 (0.65) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL462304 | 0.76 | LPAR1 (0.66) | MEN1KMT2ASMN1; SMN2LMNANLRP3 | |
| SCHEMBL9729953 | 0.75 | — | — | |
| SCHEMBL9728949 | 0.75 | — | — | |
| SCHEMBL14014120 | 0.75 | RAB9A (0.80) | NPC1RAB9AMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5162360-A | Treating hypercholesterolemia and atherosclerosis; ACAT acyl-coenzyme A:-cholesterol acyltransferase | WARNER-LAMBERT COMPANY (US) | 1992-11-10 | — | — | US | disclosed |