Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | GALR3 | O60755 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 8/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.43 |
| ▸ | PDE4A | P27815 | 5/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | SLFN12 | Q8IYM2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9729452 | 0.88 | MAPT (0.45) | MAPTGALR3THRBTP53PDE3B | |
| SCHEMBL10430088 | 0.85 | TP53 (0.45) | MAPTGALR3THRBTP53PDE3B | |
| SCHEMBL7266508 | 0.84 | GALR3 (0.67) | MAPTGALR3THRBTP53PDE3B | |
| SCHEMBL9730211 | 0.80 | TP53 (0.42) | MAPTTP53PDE3BPDE3APDE4A | |
| SCHEMBL3440851 | 0.79 | MAPT (0.64) | MAPTGALR3THRBPDE3BPDE3A | |
| SCHEMBL3441023 | 0.77 | PDE3B (0.50) | MAPTGALR3THRBPDE3BPDE3A | |
| SCHEMBL10430009 | 0.76 | CTPS1 (0.34) | MAPTGALR3THRBTP53PDE3B | |
| Iodide SCHEMBL9730223 | 0.75 | GALR3 (0.39) | MAPTGALR3THRBTP53PDE3B | |
| SCHEMBL10429892 | 0.74 | MAPT (0.34) | MAPTGALR3THRBTP53PDE3B | |
| SCHEMBL7268664 | 0.74 | GALR3 (0.63) | MAPTGALR3THRBTP53PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5108998-A | CARDIOTONIC THIADIAZINE DERIVATIVES | HEUMANN PHARMA GMBH & CO. (DE) | 1992-04-28 | — | — | US | disclosed |
| US-5082942-A | NOVEL DERIVATIVES OF TETRAHYDRO-2,3,6,7,1H,5H,11H-(1)BENZOPYRANO(6,7,8,IJ)QUINOLIZINONE-11 USABLE AS MARKERS OF ORGANIC COMPOUNDS FOR THE DETECTION OF SAID COMPOUNDS BY CHEMILUMINESCENCE OR FLUORESCENCE | LABORATORIES EUROBIO (FR) | 1992-01-21 | — | — | US | disclosed |
| EP-0399196-A1 | Diazine derivatives, process for their preparation, and medicaments containing these compounds | HEUMANN PHARMA GMBH & CO (DE) | 1990-11-28 | — | — | EP | disclosed |