Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR3 | O60755 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 8/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.37 |
| ▸ | PDE4A | P27815 | 5/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SLFN12 | Q8IYM2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | FBP1 | P09467 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9729178 | 0.75 | MAPT (0.46) | GALR3MAPTTHRBPDE3BPDE3A | |
| SCHEMBL9729452 | 0.74 | MAPT (0.45) | GALR3MAPTTHRBPDE3BPDE3A | |
| SCHEMBL3440851 | 0.73 | MAPT (0.64) | GALR3MAPTTHRBPDE3BPDE3A | |
| SCHEMBL3441023 | 0.69 | PDE3B (0.50) | GALR3MAPTTHRBPDE3BPDE3A | |
| SCHEMBL10430088 | 0.68 | TP53 (0.45) | GALR3MAPTTHRBPDE3BPDE3A | |
| Iodide SCHEMBL9729167 | 0.65 | MAPT (0.53) | GALR3MAPTTHRBPDE3BPDE3A | |
| SCHEMBL3440910 | 0.64 | PDE3B (0.62) | GALR3MAPTTHRBPDE3BPDE3A | |
| SCHEMBL9729357 | 0.64 | GALR3 (0.45) | GALR3MAPTTHRBPDE3BPDE3A | |
| SCHEMBL9729253 | 0.64 | MAPT (0.54) | GALR3MAPTTHRBPDE3BPDE3A | |
| Iodide SCHEMBL9729749 | 0.64 | MAPT (0.51) | GALR3MAPTTHRBPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5108998-A | CARDIOTONIC THIADIAZINE DERIVATIVES | HEUMANN PHARMA GMBH & CO. (DE) | 1992-04-28 | — | — | US | disclosed |