Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | GRK6 | P43250 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10430050 | 0.86 | MAPT (0.44) | POLBGAAMAPTALDH1A1RAB9A | |
| SCHEMBL9729178 | 0.80 | MAPT (0.46) | TP53POLBGAACTPS1MAPT | |
| SCHEMBL7266508 | 0.76 | GALR3 (0.67) | TP53GAAMAPTALDH1A1PDE3B | |
| SCHEMBL31250016 | 0.70 | MAPT (0.54) | POLBGAACTPS1MAPTALDH1A1 | |
| SCHEMBL28536070 | 0.70 | CTPS1 (0.51) | TP53POLBGAACTPS1MAPT | |
| Bromide SCHEMBL11509454 | 0.69 | ALDH1A1 (0.69) | POLBGAACTPS1MAPTALDH1A1 | |
| SCHEMBL7267653 | 0.69 | PDE4A (0.45) | POLBGAAMAPTALDH1A1PDE3B | |
| SCHEMBL10760147 | 0.68 | MAPT (0.53) | GAAMAPTALDH1A1PDE3BPDE3A | |
| SCHEMBL9729452 | 0.67 | MAPT (0.45) | TP53POLBGAAMAPTALDH1A1 | |
| SCHEMBL15828725 | 0.67 | MAPT (0.58) | TP53POLBGAACTPS1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5108998-A | CARDIOTONIC THIADIAZINE DERIVATIVES | HEUMANN PHARMA GMBH & CO. (DE) | 1992-04-28 | — | — | US | disclosed |
| EP-0399196-A1 | Diazine derivatives, process for their preparation, and medicaments containing these compounds | HEUMANN PHARMA GMBH & CO (DE) | 1990-11-28 | — | — | EP | disclosed |