Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 3/20 | 0.36 |
| ▸ | MMP8 | P22894 | 3/20 | 0.36 |
| ▸ | MMP12 | P39900 | 3/20 | 0.36 |
| ▸ | MMP13 | P45452 | 3/20 | 0.36 |
| ▸ | MMP14 | P50281 | 3/20 | 0.36 |
| ▸ | MMP16 | P51512 | 3/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9729250 | 0.89 | AKR1B1 (0.41) | AKR1B1HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL29837260 | 0.81 | HDAC3 (0.36) | HDAC3HDAC1HDAC2NCOR2TP53 | |
| SCHEMBL994015 | 0.80 | AKR1B1 (0.43) | AKR1B1L3MBTL1PTGS2MMP2MMP8 | |
| SCHEMBL27572033 | 0.80 | TP53 (0.54) | HDAC3HDAC1HDAC2NCOR2TP53 | |
| SCHEMBL28261500 | 0.78 | TSHR (0.41) | HDAC3HDAC1HDAC2NCOR2TP53 | |
| SCHEMBL18203948 | 0.75 | CXCL8 (0.36) | HDAC3HDAC1HDAC2NCOR2NR1H4 | |
| SCHEMBL26702620 | 0.75 | ALDH1A1 (0.35) | HDAC3HDAC1HDAC2NCOR2L3MBTL1 | |
| SCHEMBL28038835 | 0.74 | TP53 (0.54) | TP53L3MBTL1CYP2C19MEN1CYP3A4 | |
| SCHEMBL29836138 | 0.74 | TSHR (0.37) | MMP2MMP12MMP13MMP14CXCL8 | |
| SCHEMBL7375645 | 0.73 | TSHR (0.37) | HDAC3HDAC1HDAC2NCOR2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5102667-A | Antiallergens, antiinflammatory agents, nervous system disorders, immunology, psychological disorders | RHONE-POULENC SANTE (FR) | 1992-04-07 | — | — | US | disclosed |