SCHEMBL9729287

SCHEMBL9729287

CCOC(=O)[C@@H]1CC2(CC[C@H]1N)OCCO2

nearest known ligand 0.37

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.37
CYP2C19 P33261 3/20 0.37
MAPK1 P28482 2/20 0.37
TP53 P04637 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
POLB P06746 1/20 0.36
PPM1B O75688 1/20 0.34
PTPN1 P18031 1/20 0.34
PPP1CC P36873 1/20 0.34
ALDH1A1 P00352 5/20 0.33
CYP2C9 P11712 2/20 0.32
CYP2D6 P10635 1/20 0.32
LMNA P02545 3/20 0.32
KDM4E B2RXH2 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9729278 1.00 CYP3A4 (0.37) CYP3A4CYP2C19MAPK1TP53SMN1; SMN2
SCHEMBL12156499 1.00 CYP3A4 (0.37) CYP3A4CYP2C19MAPK1TP53SMN1; SMN2
SCHEMBL13411394 1.00 CYP3A4 (0.37) CYP3A4CYP2C19MAPK1TP53SMN1; SMN2
SCHEMBL9728986 1.00 CYP3A4 (0.37) CYP3A4CYP2C19MAPK1TP53SMN1; SMN2
SCHEMBL12598334 1.00 CYP3A4 (0.37) CYP3A4CYP2C19MAPK1TP53SMN1; SMN2
Bromide SCHEMBL1770016 0.99 CYP3A4 (0.36) CYP3A4CYP2C19MAPK1TP53SMN1; SMN2
SCHEMBL1841367 0.84 ALDH1A1 (0.43) CYP3A4CYP2C19MAPK1POLBALDH1A1
SCHEMBL2988940 0.81 CYP3A4 (0.38) CYP3A4CYP2C19MAPK1TP53SMN1; SMN2
SCHEMBL31721580 0.81 CYP3A4 (0.38) CYP3A4CYP2C19MAPK1TP53SMN1; SMN2
SCHEMBL13411367 0.81 OPRK1 (0.34) CYP3A4CYP2C19MAPK1TP53SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5134143-A Dopamine Agonists ELI LILLY AND COMPANY (US) 1992-07-28 US disclosed
US-4977160-A DOPAMINE AGONISTS; PARKINSON*S DISEASE ELI LILLY AND COMPANY (US) 1990-12-11 US disclosed
US-4826986-A DOPAMINE AGONISTS ELI LILLY AND COMPANY (US) 1989-05-02 US disclosed