Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 8/20 | 0.47 |
| ▸ | GSK3A | P49840 | 3/20 | 0.46 |
| ▸ | PIM1 | P11309 | 3/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.44 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3176935 | 0.83 | TLR8 (0.82) | TLR8KDM4EMAP2K1CLK4DYRK1B | |
| SCHEMBL3155668 | 0.82 | TLR8 (0.72) | TLR8KDM4EMAP2K1CLK4DYRK1B | |
| SCHEMBL8331920 | 0.81 | TLR8 (1.00) | TLR8KDM4EMAP2K1CLK4DYRK1B | |
| SCHEMBL9877202 | 0.78 | TLR8 (0.67) | TLR8KDM4EMAP2K1CLK4DYRK1B | |
| SCHEMBL9728825 | 0.78 | TLR8 (0.67) | TLR8KDM4EMAP2K1CLK4DYRK1B | |
| SCHEMBL4655828 | 0.72 | BRAF (0.63) | TLR8KDM4EMAP2K1CLK4DYRK1B | |
| SCHEMBL10736560 | 0.71 | TLR8 (0.49) | TLR8KDM4EMAP2K1CLK4DYRK1B | |
| SCHEMBL4656020 | 0.71 | BRAF (0.80) | TLR8BRAFGSK3APIM1EPHA2 | |
| SCHEMBL11463600 | 0.70 | BRAF (0.79) | KDM4EBRAF | |
| SCHEMBL11472378 | 0.70 | MAP2K1 (0.65) | KDM4EMAP2K1CLK4DYRK1BBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5169850-A | Neurotropic or hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1992-12-08 | — | — | US | disclosed |