Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 5/20 | 0.46 |
| ▸ | GSK3A | P49840 | 4/20 | 0.46 |
| ▸ | AKT1 | P31749 | 2/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.46 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | NEK2 | P51955 | 1/20 | 0.42 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9728825 | 1.00 | TLR8 (0.67) | TLR8KDM4EMAP2K1CLK4DYRK1B | |
| SCHEMBL9728968 | 0.88 | CLK4 (0.61) | TLR8KDM4EMAP2K1CLK4DYRK1B | |
| SCHEMBL9728973 | 0.88 | CLK4 (0.61) | TLR8KDM4EMAP2K1CLK4DYRK1B | |
| SCHEMBL9877207 | 0.86 | KDM4E (0.67) | TLR8KDM4EBRAF | |
| SCHEMBL3176935 | 0.82 | TLR8 (0.82) | TLR8KDM4EMAP2K1CLK4DYRK1B | |
| SCHEMBL8331920 | 0.80 | TLR8 (1.00) | TLR8KDM4EMAP2K1CLK4DYRK1B | |
| SCHEMBL9729664 | 0.78 | TLR8 (0.68) | TLR8KDM4EMAP2K1CLK4DYRK1B | |
| SCHEMBL3155668 | 0.77 | TLR8 (0.72) | TLR8KDM4EMAP2K1CLK4DYRK1B | |
| SCHEMBL9729772 | 0.73 | MAP2K1 (0.47) | TLR8KDM4EMAP2K1CLK4DYRK1B | |
| SCHEMBL9877172 | 0.70 | NTRK1 (0.64) | KDM4EPIM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5059691-A | Anxiolytic agents; hypotensive agents; nervous system disorders; cognition activators | AMERICAN CYANAMID COMPANY (US) | 1991-10-22 | — | — | US | disclosed |