Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.43 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.43 |
| ▸ | PIM1 | P11309 | 4/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 3/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9878097 | 0.81 | MAP2K1 (0.49) | MAP2K1CLK4DYRK1BTLR8KDM4E | |
| SCHEMBL9878106 | 0.81 | MAP2K1 (0.49) | MAP2K1CLK4DYRK1BTLR8KDM4E | |
| SCHEMBL11167079 | 0.78 | MAP2K1 (0.59) | MAP2K1CLK4DYRK1BTLR8KDM4E | |
| SCHEMBL11162191 | 0.78 | KDM4E (0.65) | MAP2K1CLK4DYRK1BTLR8KDM4E | |
| SCHEMBL11164960 | 0.77 | BRAF (0.59) | MAP2K1CLK4DYRK1BTLR8KDM4E | |
| SCHEMBL9728973 | 0.77 | CLK4 (0.61) | MAP2K1CLK4DYRK1BTLR8KDM4E | |
| SCHEMBL9728968 | 0.77 | CLK4 (0.61) | MAP2K1CLK4DYRK1BTLR8KDM4E | |
| Hydrochloric Acid SCHEMBL11366478 | 0.77 | KDM4E (0.64) | MAP2K1CLK4DYRK1BTLR8KDM4E | |
| SCHEMBL9728658 | 0.76 | MAP2K1 (0.78) | MAP2K1CLK4DYRK1BTLR8KDM4E | |
| SCHEMBL11167453 | 0.75 | MAP2K1 (0.57) | MAP2K1CLK4DYRK1BTLR8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5169850-A | Neurotropic or hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1992-12-08 | — | — | US | disclosed |
| US-5059691-A | Anxiolytic agents; hypotensive agents; nervous system disorders; cognition activators | AMERICAN CYANAMID COMPANY (US) | 1991-10-22 | — | — | US | disclosed |