Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.61 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.61 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.61 |
| ▸ | PIM1 | P11309 | 6/20 | 0.53 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | GSK3A | P49840 | 4/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.52 |
| ▸ | AKT1 | P31749 | 2/20 | 0.52 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.52 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.52 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.50 |
| ▸ | NEK2 | P51955 | 1/20 | 0.50 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9728968 | 1.00 | CLK4 (0.61) | CLK4MAP2K1DYRK1BPIM1LIMK1 | |
| SCHEMBL9877202 | 0.88 | TLR8 (0.67) | CLK4MAP2K1DYRK1BPIM1LIMK1 | |
| SCHEMBL9728825 | 0.88 | TLR8 (0.67) | CLK4MAP2K1DYRK1BPIM1LIMK1 | |
| SCHEMBL9877207 | 0.85 | KDM4E (0.67) | KDM4ETLR8 | |
| SCHEMBL9877170 | 0.79 | NTRK1 (0.64) | PIM1KDM4EALDH1A1GAAHTT | |
| SCHEMBL9877172 | 0.79 | NTRK1 (0.64) | PIM1KDM4EALDH1A1GAAHTT | |
| SCHEMBL9729772 | 0.77 | MAP2K1 (0.47) | CLK4MAP2K1DYRK1BPIM1LIMK1 | |
| SCHEMBL8338772 | 0.76 | CLK4 (1.00) | CLK4MAP2K1DYRK1BPIM1LIMK1 | |
| SCHEMBL7362738 | 0.75 | CLK4 (0.73) | CLK4MAP2K1DYRK1BPIM1LIMK1 | |
| SCHEMBL9729081 | 0.73 | SMPD3 (0.48) | KDM4EALDH1A1IRAK4HTTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5059691-A | Anxiolytic agents; hypotensive agents; nervous system disorders; cognition activators | AMERICAN CYANAMID COMPANY (US) | 1991-10-22 | — | — | US | claimed |
| US-5169850-A | Neurotropic or hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1992-12-08 | — | — | US | disclosed |
| US-5059691-A | Anxiolytic agents; hypotensive agents; nervous system disorders; cognition activators | AMERICAN CYANAMID COMPANY (US) | 1991-10-22 | — | — | US | disclosed |