SCHEMBL9730100

SCHEMBL9730100

O=C(Oc1cc([N+](=O)[O-])c(Cl)cc1F)Oc1cc([N+](=O)[O-])c(Cl)cc1F

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
VCAM1 P19320 2/20 0.42
ALDH1A1 P00352 2/20 0.42
CYP3A4 P08684 1/20 0.42
HSPB1 P04792 2/20 0.40
MAPK1 P28482 2/20 0.40
TSHR P16473 1/20 0.40
SLC9A1 P19634 1/20 0.39
LMNA P02545 2/20 0.39
RAF1 P04049 1/20 0.38
MAPT P10636 1/20 0.38
HPGD P15428 1/20 0.38
GFER P55789 1/20 0.38
PAX8 Q06710 1/20 0.38
MERTK Q12866 1/20 0.37
GPR35 Q9HC97 1/20 0.37
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
F2 P00734 1/20 0.36
PRSS1 P07477 1/20 0.36
PRSS2 P07478 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24453320 0.87 POLB (0.45) VCAM1ALDH1A1LMNAMAPTHPGD
SCHEMBL8760591 0.87 TDP1 (0.40) VCAM1ALDH1A1CYP3A4HSPB1MAPK1
SCHEMBL11347001 0.85 VCAM1 (0.46) VCAM1ALDH1A1CYP3A4MAPK1TSHR
SCHEMBL30225347 0.85 VCAM1 (0.46) VCAM1ALDH1A1CYP3A4MAPK1TSHR
SCHEMBL9730053 0.80 ALDH1A1 (0.47) ALDH1A1CYP3A4HSPB1MAPK1TSHR
SCHEMBL2030437 0.79 CUL4A (0.42) ALDH1A1CYP3A4MAPK1LMNARAF1
SCHEMBL2477068 0.77 TSHR (0.52) VCAM1ALDH1A1CYP3A4MAPK1TSHR
SCHEMBL29653309 0.77 TSHR (0.52) VCAM1ALDH1A1CYP3A4MAPK1TSHR
SCHEMBL9814277 0.76 CUL4A (0.45) VCAM1ALDH1A1CYP3A4MAPK1SLC9A1
SCHEMBL7215856 0.76 HTT (0.41) ALDH1A1CYP3A4HSPB1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5136868-A HERBICIDAL 1-ARYL-4-SUBSTITUTED-1,4-DIHYDRO-5H-TETRAZOL-5-ONES AND SULFUR ANALOGS THEREOF FMC CORPORATION (US) 1992-08-11 US disclosed
EP-0161304-B1 HERBICIDAL 1-ARYL-4-SUBSTITUTED-1,4-DIHYDRO-5H-TETRAZOL-5-ONES AND SULFUR ANALOGS THEREOF FMC Corporation (US) 1990-01-10 EP disclosed
EP-0161304-A4 HERBICIDAL 1-ARYL-4-SUBSTITUTED-1,4-DIHYDRO-5H-TETRAZOL-5-ONES AND SULFUR ANALOGS THEREOF. FMC CORP (US) 1986-04-15 EP disclosed
EP-0161304-A1 HERBICIDAL 1-ARYL-4-SUBSTITUTED-1,4-DIHYDRO-5H-TETRAZOL-5-ONES AND SULFUR ANALOGS THEREOF. FMC CORP (US) 1985-11-21 EP disclosed
WO-1985001939-A1 HERBICIDAL 1-ARYL-4-SUBSTITUTED-1,4-DIHYDRO-5H-TETRAZOL-5-ONES AND SULFUR ANALOGS THEREOF FMC CORPORATION (US) 1985-05-09 WO disclosed