Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 18/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9730672 | 0.83 | ALOX5 (0.55) | ALOX5ALOX12PTGS1PTGS2 | |
| SCHEMBL16592669 | 0.80 | CYP19A1 (0.40) | ALOX5NFKB1NFKB2RELAPTGS2 | |
| SCHEMBL31519356 | 0.79 | KDM4E (0.46) | NFKB1NFKB2RELACYP19A1 | |
| SCHEMBL10600995 | 0.79 | KDM4E (0.46) | NFKB1NFKB2RELACYP19A1 | |
| Formamide SCHEMBL9730794 | 0.76 | ALOX5 (0.63) | ALOX5ALOX12PTGS1PTGS2 | |
| SCHEMBL9729708 | 0.69 | ALOX5 (0.54) | ALOX5ALOX12PTGS1PTGS2 | |
| SCHEMBL7148188 | 0.67 | PTGS2 (0.51) | ALOX5ALOX12PTGS1PTGS2 | |
| SCHEMBL9729627 | 0.67 | ALOX5 (0.59) | ALOX5NFKB1NFKB2RELA | |
| SCHEMBL6094274 | 0.66 | PTGS2 (0.73) | PTGS1PTGS2 | |
| SCHEMBL6092337 | 0.66 | PTGS2 (0.73) | PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155130-A | Lipoxygenase inhibitors | CIBA-GEIGY CORPORATION (US) | 1992-10-13 | — | — | US | disclosed |
| EP-0412939-A2 | Certain benzopyran and benzothiopyran derivatives | CIBA-GEIGY AG (CH) | 1991-02-13 | — | — | EP | disclosed |