Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | PPID | Q08752 | 1/20 | 0.33 |
| ▸ | MDM4 | O15151 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PRNP | P04156 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30895707 | 0.89 | MEN1 (0.36) | ALDH1A1MEN1KMT2APIN1NPC1 | |
| SCHEMBL9300094 | 0.88 | KCNA5 (0.37) | TSHRALDH1A1KMT2AMAPT | |
| SCHEMBL9856975 | 0.88 | ALDH1A1 (0.34) | TSHRALDH1A1MEN1KMT2APIN1 | |
| SCHEMBL9856810 | 0.88 | TSHR (0.34) | TSHRALDH1A1MEN1KMT2APIN1 | |
| SCHEMBL9347640 | 0.88 | TSHR (0.44) | TSHRALDH1A1MEN1KMT2APIN1 | |
| SCHEMBL10694453 | 0.87 | PTPRC (0.34) | ALDH1A1MEN1KMT2AMAPTPOLB | |
| SCHEMBL10434071 | 0.87 | PTPRC (0.34) | ALDH1A1MEN1KMT2AMAPTPOLB | |
| SCHEMBL10433967 | 0.87 | MAPT (0.35) | CYP3A4MAPT | |
| SCHEMBL9828488 | 0.87 | MAPT (0.35) | CYP3A4MAPT | |
| SCHEMBL12787298 | 0.86 | TSHR (0.39) | TSHRALDH1A1MEN1KMT2APIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5081136-A | 1,2,3-TRIAZOLE COMPOUNDS ACTIVE AS INHIBITORS OF THE ENZYME HMG-COA REDUCTASE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ZAMBON GROUP S.P.A. (IT) | 1992-01-14 | — | — | US | disclosed |
| EP-0433842-A2 | 1,2,3-Triazole derivatives active as inhibitors of the enzyme HMG-COA reductase and pharmaceutical compositions containing them | ZAMBON GROUP S.p.A. (IT) | 1991-06-26 | — | — | EP | disclosed |
| US-4939159-A | Azaindole derivatives useful as cholesterol biosynthesis inhibitors | SANDOZ PHARM. CORP. (US) | 1990-07-03 | — | — | US | disclosed |
| US-4613610-A | TREATING ATHEROSCLEROSIS AND HYPERLIPEMIA | SANDOZ PHARMACEUTICALS CORP. (US) | 1986-09-23 | — | — | US | disclosed |