Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PRNP | P04156 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | MDM4 | O15151 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PPID | Q08752 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9856975 | 0.92 | ALDH1A1 (0.34) | TSHRALDH1A1MEN1KMT2AF2 | |
| SCHEMBL9730290 | 0.88 | TSHR (0.38) | TSHRALDH1A1PRNPMEN1KMT2A | |
| SCHEMBL10779090 | 0.84 | TSHR (0.39) | TSHRALDH1A1PRNPMEN1KMT2A | |
| SCHEMBL9347640 | 0.83 | TSHR (0.44) | TSHRALDH1A1PRNPMEN1KMT2A | |
| SCHEMBL9857119 | 0.81 | SLC6A3 (0.32) | TSHRMEN1KMT2A | |
| SCHEMBL12787299 | 0.81 | TSHR (0.38) | TSHRALDH1A1PRNPMEN1KMT2A | |
| SCHEMBL23529640 | 0.80 | TSHR (0.41) | TSHRALDH1A1PRNPMEN1KMT2A | |
| SCHEMBL2915807 | 0.80 | TSHR (0.41) | TSHRALDH1A1PRNPMEN1KMT2A | |
| SCHEMBL29772371 | 0.80 | TSHR (0.41) | TSHRALDH1A1PRNPMEN1KMT2A | |
| SCHEMBL2915808 | 0.80 | TSHR (0.41) | TSHRALDH1A1PRNPMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436851-A1 | Compounds active as inhibitors of the enzyme HMG-CoA reductase and pharmaceutical compositions containing them | ZAMBON GROUP S.p.A. (IT) | 1991-07-17 | — | — | EP | disclosed |