Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.71 |
| ▸ | SHBG | P04278 | 1/20 | 0.71 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.71 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.70 |
| ▸ | MAPT | P10636 | 6/20 | 0.63 |
| ▸ | RAB9A | P51151 | 4/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.63 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL485061 | 0.87 | ESR1 (0.65) | ESR1SHBGESR2PIK3CAMAPT | |
| SCHEMBL3586687 | 0.84 | ESR1 (0.81) | ESR1SHBGESR2PIK3CAMAPT | |
| SCHEMBL29514772 | 0.84 | ESR1 (0.81) | ESR1SHBGESR2PIK3CAMAPT | |
| SCHEMBL30503014 | 0.83 | ESR1 (1.00) | ESR1SHBGESR2MAPTRAB9A | |
| SCHEMBL312243 | 0.83 | ESR1 (1.00) | ESR1SHBGESR2MAPTRAB9A | |
| SCHEMBL2334134 | 0.83 | MAPT (0.63) | ESR1SHBGESR2PIK3CAMAPT | |
| SCHEMBL3068438 | 0.82 | ESR1 (0.77) | ESR1SHBGESR2PIK3CAMAPT | |
| SCHEMBL31511910 | 0.82 | ESR1 (0.77) | ESR1SHBGESR2PIK3CAMAPT | |
| SCHEMBL484705 | 0.81 | ESR1 (0.57) | ESR1SHBGESR2PIK3CAMAPT | |
| SCHEMBL14855982 | 0.79 | ESR1 (0.72) | ESR1SHBGESR2PIK3CAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5151420-A | Cardiovascular disorders | ORION CORPORATION/ORION PHARMACEUTICA (FI) | 1992-09-29 | — | — | US | disclosed |