Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.65 |
| ▸ | SHBG | P04278 | 1/20 | 0.65 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.54 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9730612 | 0.87 | ESR1 (0.71) | ESR1SHBGESR2MAPTRAB9A | |
| SCHEMBL2334134 | 0.82 | MAPT (0.63) | ESR1SHBGESR2MAPTRAB9A | |
| SCHEMBL3586687 | 0.80 | ESR1 (0.81) | ESR1SHBGESR2MAPTRAB9A | |
| SCHEMBL29514772 | 0.80 | ESR1 (0.81) | ESR1SHBGESR2MAPTRAB9A | |
| SCHEMBL38652384 | 0.80 | ESR1 (0.81) | ESR1SHBGESR2MAPTRAB9A | |
| SCHEMBL3820741 | 0.80 | ESR1 (0.81) | ESR1SHBGESR2MAPTRAB9A | |
| SCHEMBL484705 | 0.80 | ESR1 (0.57) | ESR1SHBGESR2MAPTRAB9A | |
| SCHEMBL312243 | 0.80 | ESR1 (1.00) | ESR1SHBGESR2MAPTRAB9A | |
| SCHEMBL30503014 | 0.80 | ESR1 (1.00) | ESR1SHBGESR2MAPTRAB9A | |
| SCHEMBL3068438 | 0.79 | ESR1 (0.77) | ESR1SHBGESR2MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8314132-B2 | 5-aryl-4-(5-substituted 2,4-dihydroxyphenyl)-1,2,3-thiadiazoles as inhibitors of Hsp90 chaperone and the intermediates for production thereof | BIOTECHNOLOGIJOS INSTITUTAS (LT) | 2012-11-20 | — | — | US | claimed |
| EP-2268626-B1 | 5-ARYL-4-(5-SUBSTITUTED 2,4-DIHYDROXYPHENYL)-1,2,3-THIADIAZOLES AS INHIBITORS OF HSP90 CHAPERONE AND THE INTERMEDIATES FOR PRODUCTION THEREOF | BIOTECHNOLOGIJOS INST (LT) | 2012-02-01 | — | — | EP | claimed |
| US-20110046387-A1 | 5-ARYL-4-(5-SUBSTITUTED 2,4-DIHYDROXYPHENYL)-1,2,3-THIADIAZOLES AS INHIBITORS OF HSP90 CHAPERONE AND THE INTERMEDIATES FOR PRODUCTION THEREOF | BIOTECHNOLOGIJOS INSTITUTAS (LT) | 2011-02-24 | — | — | US | claimed |
| EP-2268626-A1 | 5-ARYL-4-(5-SUBSTITUTED 2,4-DIHYDROXYPHENYL)-1,2,3-THIADIAZOLES AS INHIBITORS OF HSP90 CHAPERONE AND THE INTERMEDIATES FOR PRODUCTION THEREOF | Biotechnologijos Institutas (LT) | 2011-01-05 | — | — | EP | claimed |
| WO-2009134110-A1 | 5-ARYL-4-(5-SUBSTITUTED 2,4-DIHYDROXYPHENYL)-1,2,3-THIADIAZOLES AS INHIBITORS OF HSP90 CHAPERONE AND THE INTERMEDIATES FOR PRODUCTION THEREOF | BIOTECHNOLOGIJOS INSTITUTAS (LT) | 2009-11-05 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046387-A1 | 5-ARYL-4-(5-SUBSTITUTED 2,4-DIHYDROXYPHENYL)-1,2,3-THIADIAZOLES AS INHIBITORS OF HSP90 CHAPERONE AND THE INTERMEDIATES FOR PRODUCTION THEREOF | HSP90AB1, HSP90AB2P, HSP90AA1 | ESR1 4017/4885SHBG 3779/4885ESR2 3033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.