SCHEMBL312243

SCHEMBL312243

O=C(Cc1ccc(O)cc1)c1ccc(O)cc1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 1.00
SHBG P04278 1/20 1.00
ESR2 Q92731 1/20 1.00
LMNA P02545 3/20 0.81
RAB9A P51151 3/20 0.81
MAPT P10636 3/20 0.81
SMN1; SMN2 Q16637 2/20 0.81
NPC1 O15118 2/20 0.81
HTT P42858 2/20 0.81
GAA P10253 1/20 0.81
ALOX12 P18054 1/20 0.81
ALDH1A1 P00352 6/20 0.73
MEN1 O00255 2/20 0.73
HPGD P15428 2/20 0.73
KMT2A Q03164 2/20 0.73
CYP3A4 P08684 1/20 0.73
ATM Q13315 1/20 0.73
ALOX5 P09917 1/20 0.69
HSP90AB1 P08238 1/20 0.61
TP53 P04637 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30503014 1.00 ESR1 (1.00) ESR1SHBGESR2LMNARAB9A
SCHEMBL30204024 0.90 LMNA (1.00) ESR1SHBGESR2LMNARAB9A
SCHEMBL22672221 0.90 ESR1 (0.81) ESR1SHBGESR2LMNARAB9A
SCHEMBL3820741 0.90 ESR1 (0.81) ESR1SHBGESR2LMNARAB9A
SCHEMBL3958571 0.90 LMNA (1.00) ESR1SHBGESR2LMNARAB9A
SCHEMBL2331741 0.90 LMNA (1.00) ESR1SHBGESR2LMNARAB9A
SCHEMBL3586687 0.90 ESR1 (0.81) ESR1SHBGESR2LMNARAB9A
SCHEMBL38652384 0.90 ESR1 (0.81) ESR1SHBGESR2LMNARAB9A
SCHEMBL29514772 0.90 ESR1 (0.81) ESR1SHBGESR2LMNARAB9A
SCHEMBL146018 0.89 ESR1 (0.80) ESR1SHBGESR2LMNARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116332893-A Synthesis method of daidzein 广东工业大学 2023-06-27 CN claimed
US-6334998-B1 PRETREATMENT WITH ESTROGEN COMPOUND, FOR EXAMPLE, ESTROGENIC ISOFLAVONE, PREVENTS PATHOLOGIC CONDITIONS ASSOCIATED WITH AMYOTROPHIC LATERAL SCLEROSIS AND DELAYS DISEASE ONSET IN INDIVIDUALS AT HIGH RISK PARKER HUGHES INSTITUTE 2002-01-01 US claimed
EP-1158975-A1 USE OF ISOFLAVONES AND/OR AFRICAN PLUM EXTRACTS FOR PREPARING A COMPOSITION DESIGNED TO INHIBIT 5$G(A)-REDUCTASE ACTIVITY, IN PHARMACOLOGY PARTICULARLY IN DERMATOLOGY, IN COSMETICS AND AS FOOD ADDITIVE Laboratoires Pharmascience (FR) 2001-12-05 EP claimed
WO-2001052840-A1 USE OF ISOFLAVONES AND/OR AFRICAN PLUM EXTRACTS FOR PREPARING A COMPOSITION DESIGNED TO INHIBIT 5$G(A)-REDUCTASE ACTIVITY, IN PHARMACOLOGY PARTICULARLY IN DERMATOLOGY, IN COSMETICS AND AS FOOD ADDITIVE LABORATOIRES PHARMASCIENCE (FR) 2001-07-26 WO claimed
WO-2001041751-A2 PHYTOESTROGENS FOR TREATING ALS PARKER HUGHES INSTITUTE (US) 2001-06-14 WO claimed
CN-116332893-A Synthesis method of daidzein 广东工业大学 2023-06-27 CN disclosed
CN-116332893-A Synthesis method of daidzein 广东工业大学 2023-06-27 CN disclosed
WO-2023278394-A1 POLYCATIONIC SALTS OF PHENOLIC COMPOUNDS AND USES THEREOF FIRMENICH INCORPORATED (US) 2023-01-05 WO disclosed
US-10548903-B2 Treatment of male androgen deficiency symptoms or diseases with sex steroid precursor combined with SERM ENDORECHERCHE, INC. (CA) 2020-02-04 US disclosed
US-20190269697-A1 A METHOD OF TREATING AND PREVENTING LOSS OF COGNITION ENDORECHERCHE, INC. (CA) 2019-09-05 US disclosed
US-20190269696-A1 METHOD OF PREVENTING ALZHEIMIER'S DISEASE ENDORECHERCHE, INC. (CA) 2019-09-05 US disclosed
US-10342805-B2 Treatment of Alzheimer's disease, loss of cognition, memory loss and dementia with sex steroid precursors in combination with selective estrogen receptor modulators ENDORECHERCHE, INC. (CA) 2019-07-09 US disclosed
US-6334998-B1 PRETREATMENT WITH ESTROGEN COMPOUND, FOR EXAMPLE, ESTROGENIC ISOFLAVONE, PREVENTS PATHOLOGIC CONDITIONS ASSOCIATED WITH AMYOTROPHIC LATERAL SCLEROSIS AND DELAYS DISEASE ONSET IN INDIVIDUALS AT HIGH RISK PARKER HUGHES INSTITUTE 2002-01-01 US disclosed
EP-1158975-A1 USE OF ISOFLAVONES AND/OR AFRICAN PLUM EXTRACTS FOR PREPARING A COMPOSITION DESIGNED TO INHIBIT 5$G(A)-REDUCTASE ACTIVITY, IN PHARMACOLOGY PARTICULARLY IN DERMATOLOGY, IN COSMETICS AND AS FOOD ADDITIVE Laboratoires Pharmascience (FR) 2001-12-05 EP disclosed
WO-2001068634-A1 4-FLUOROALKYL-2H-BENZOPYRANS WITH ANTI-ESTROGENIC ACTIVITY SCHERING AKTIENGESELLSCHAFT (DE) 2001-09-20 WO disclosed
WO-2001052840-A1 USE OF ISOFLAVONES AND/OR AFRICAN PLUM EXTRACTS FOR PREPARING A COMPOSITION DESIGNED TO INHIBIT 5$G(A)-REDUCTASE ACTIVITY, IN PHARMACOLOGY PARTICULARLY IN DERMATOLOGY, IN COSMETICS AND AS FOOD ADDITIVE LABORATOIRES PHARMASCIENCE (FR) 2001-07-26 WO disclosed
US-6262270-B1 HYDROXYPHENYLACETOPHENONE DERIVATIVE IS REACTED WITH N-ETHOXYBENZYL PIPERIDINE COMPOUND IN PRESENCE OF PIPERIDINE AND HINDERED AMINE BASE AND ALKANOL TO PRODUCE PURE ANTIESTROGEN COMPOUND SCHERING CORPORATION 2001-07-17 US disclosed
WO-2001041751-A2 PHYTOESTROGENS FOR TREATING ALS PARKER HUGHES INSTITUTE (US) 2001-06-14 WO disclosed
US-5151420-A Cardiovascular disorders ORION CORPORATION/ORION PHARMACEUTICA (FI) 1992-09-29 US disclosed
EP-0359439-A1 Substituted pyridazinones ORION-YHTYMÄ OY (FI) 1990-03-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190269697-A1 A METHOD OF TREATING AND PREVENTING LOSS OF COGNITION SHBG, BRCA1, CYP19A1 ESR1 15/4885SHBG 1/4885ESR2 5/4885
US-20190269696-A1 METHOD OF PREVENTING ALZHEIMIER'S DISEASE BRCA1, SHBG, CYP19A1 ESR1 11/4885SHBG 2/4885ESR2 5/4885
US-10342805-B2 Treatment of Alzheimer's disease, loss of cognition, memory loss and dementia with sex steroid precursors in combination with selective estrogen receptor modulators BRCA1, SHBG, CYP19A1 ESR1 5/4885SHBG 2/4885ESR2 6/4885
US-10548903-B2 Treatment of male androgen deficiency symptoms or diseases with sex steroid precursor combined with SERM SHBG, CYP19A1, AR ESR1 52/4885SHBG 1/4885ESR2 46/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.