Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH2 | P05091 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP7 | P09237 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ECE1 | P42892 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9732351 | 0.95 | KMT2A (0.39) | ALDH2ACEKMT2AMEN1ALDH1A1 | |
| SCHEMBL9730881 | 0.85 | ALDH1A1 (0.39) | ALDH2ACEKMT2AMEN1ALDH1A1 | |
| SCHEMBL9730825 | 0.81 | HPGD (0.39) | ALDH2KMT2AMEN1ALDH1A1KDM1A | |
| SCHEMBL23573535 | 0.67 | KDM1A (0.41) | ALDH2KMT2AKDM1AOPRL1 | |
| SCHEMBL390634 | 0.66 | MME (0.46) | ACEKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL29445859 | 0.66 | MME (0.46) | ACEKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL28706326 | 0.66 | MME (0.46) | ACEKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL1114718 | 0.65 | CA1 (0.41) | MMP1 | |
| SCHEMBL27258760 | 0.65 | MTNR1A (0.44) | ALDH2ALDH1A1KDM1AOPRL1 | |
| SCHEMBL8315751 | 0.65 | KCNQ2 (0.44) | ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0518943-A1 | MERCAPTOACYL AMINOLACTAM ENDOPEPTIDASE INHIBITORS | SCHERING CORPORATION (US) | 1992-12-23 | — | — | EP | claimed |
| US-5075302-A | Treating hypertension, congestive heart failure | SCHERING CORPORATION (US) | 1991-12-24 | — | — | US | claimed |
| WO-1991013870-A1 | MERCAPTOACYL AMINOLACTAM ENDOPEPTIDASE INHIBITORS | SCHERING CORPORATION (US) | 1991-09-19 | — | — | WO | claimed |