Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | S100A4 | P26447 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | NQO2 | P16083 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9732353 | 0.90 | EGFR (0.49) | EGFRPOLBKDM4EALDH1A1GAA | |
| SCHEMBL9731308 | 0.75 | MAPT (0.56) | EGFRPOLBKDM4EALDH1A1GAA | |
| SCHEMBL9730944 | 0.74 | MAPT (0.55) | EGFRPOLBKDM4EALDH1A1GAA | |
| Formamide SCHEMBL9730985 | 0.74 | MEN1 (0.35) | POLBALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL9732763 | 0.72 | EGFR (0.41) | EGFRPOLBKDM4EALDH1A1GAA | |
| SCHEMBL9731602 | 0.71 | EGFR (0.40) | EGFRPOLBKDM4EALDH1A1GAA | |
| SCHEMBL9732588 | 0.71 | EGFR (0.41) | EGFRPOLBKDM4EALDH1A1GAA | |
| SCHEMBL27244052 | 0.70 | MEN1 (0.33) | POLBALDH1A1GAAMAPTTDP1 | |
| SCHEMBL27244048 | 0.70 | MEN1 (0.33) | POLBALDH1A1GAAMAPTTDP1 | |
| SCHEMBL9731363 | 0.70 | MAPT (0.49) | EGFRPOLBKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5122537-A | Tyrosine kinase inhibitors | FARMITALIA CARLO ERBA S.R.L. (IT) | 1992-06-16 | — | — | US | disclosed |