Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.55 |
| ▸ | TAS1R3 | Q7RTX0 | 5/20 | 0.54 |
| ▸ | TAS1R1 | Q7RTX1 | 5/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | TAS1R2 | Q8TE23 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29131632 | 0.85 | OPRK1 (0.59) | KMT2AALDH1A1HTTEPHX2MEN1 | |
| SCHEMBL29131630 | 0.85 | OPRK1 (0.59) | KMT2AALDH1A1HTTEPHX2MEN1 | |
| SCHEMBL54832 | 0.81 | HTT (0.61) | KMT2AALDH1A1HTTMEN1EPHX1 | |
| SCHEMBL29131636 | 0.81 | KMT2A (0.54) | KMT2AALDH1A1HTTEPHX2MEN1 | |
| SCHEMBL29131637 | 0.81 | KMT2A (0.54) | KMT2AALDH1A1HTTEPHX2MEN1 | |
| SCHEMBL9731131 | 0.79 | ALDH1A1 (0.75) | KMT2AALDH1A1HTTEPHX2MEN1 | |
| SCHEMBL5651521 | 0.79 | TAOK3 (0.58) | KMT2AALDH1A1HTTEPHX2MEN1 | |
| SCHEMBL29131614 | 0.79 | EPHX2 (0.60) | KMT2AALDH1A1HTTEPHX2MEN1 | |
| SCHEMBL29131610 | 0.79 | EPHX2 (0.60) | KMT2AALDH1A1HTTEPHX2MEN1 | |
| SCHEMBL18351574 | 0.78 | TAOK1 (0.57) | KMT2AALDH1A1HTTMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5151446-A | Neurological disorders or cardiovascular disorders | NORTHWESTERN UNIVERSITY (US) | 1992-09-29 | — | — | US | disclosed |
| US-5071875-A | Nervous system, psychological disorders; sleep cycle, skin dis coloration | NORTHWESTERN UNIVERSITY (US) | 1991-12-10 | — | — | US | disclosed |
| EP-0420064-A2 | Substituted 2-amidotetralins as melatonin agonists and antagonists | NORTHWESTERN UNIVERSITY (US) | 1991-04-03 | — | — | EP | disclosed |