Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.51 |
| ▸ | HRH1 | P35367 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.46 |
| ▸ | CCR3 | P51677 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29263649 | 0.92 | GRIN2B (0.50) | HRH3HRH1KDM4ESMN1; SMN2CXCR4 | |
| SCHEMBL29263605 | 0.85 | HRH3 (0.54) | HRH3HRH1THRBL3MBTL1TP53 | |
| SCHEMBL29263688 | 0.85 | KDM4E (0.61) | KDM4ESMN1; SMN2CXCR4L3MBTL1ALDH1A1 | |
| SCHEMBL16026529 | 0.82 | THRB (0.61) | HRH3HRH1THRBTP53 | |
| SCHEMBL29922137 | 0.82 | THRB (0.61) | HRH3HRH1THRBTP53 | |
| SCHEMBL17828182 | 0.82 | HRH3 (0.61) | HRH3THRBTP53 | |
| SCHEMBL1305923 | 0.81 | HRH1 (0.59) | HRH3HRH1THRBTP53 | |
| SCHEMBL1308893 | 0.79 | PRMT3 (0.61) | HRH3HRH1KDM4ESMN1; SMN2CCR3 | |
| SCHEMBL868571 | 0.79 | HRH3 (0.56) | HRH3HRH1THRBALDH1A1TP53 | |
| SCHEMBL3939455 | 0.78 | HRH3 (0.55) | HRH3THRBALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118255685-A | Tricyclic compound, pharmaceutical composition and application thereof | 珂阑(上海)医药科技有限公司 | 2024-06-28 | — | — | CN | disclosed |
| US-5112824-A | Benzofurazan compounds | MERCK & CO., INC. (US) | 1992-05-12 | — | — | US | disclosed |
| US-5032604-A | Class III antiarrhythmic agents | MERCK & CO., INC. (US) | 1991-07-16 | — | — | US | disclosed |
| EP-0431944-A2 | Benzofurazan derivatives having antiarrhythmic properties | MERCK & CO. INC. (US) | 1991-06-12 | — | — | EP | disclosed |