Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.51 |
| ▸ | HTR3B | O95264 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | THPO | P40225 | 1/20 | 0.51 |
| ▸ | HTR3A | P46098 | 1/20 | 0.51 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.51 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3856968 | 0.82 | ALDH1A1 (0.48) | ALDH1A1HTR3EHTR3BCYP1A2CYP3A4 | |
| SCHEMBL9318637 | 0.80 | TYMS (0.38) | ALDH1A1HTR3EHTR3BCYP1A2CYP3A4 | |
| SCHEMBL9318307 | 0.80 | NQO2 (0.40) | ALDH1A1HTR3EHTR3BCYP1A2CYP3A4 | |
| SCHEMBL9318047 | 0.80 | ALDH1A1 (0.43) | ALDH1A1HTR3EHTR3BCYP1A2CYP3A4 | |
| SCHEMBL6699333 | 0.78 | MAPT (0.39) | ALDH1A1CYP1A2LMNANPSR1 | |
| SCHEMBL28752901 | 0.78 | HRH3 (0.37) | HTR3EHTR3BSLC6A4HTR3AHTR3D | |
| SCHEMBL27627374 | 0.78 | BACE1 (0.41) | — | |
| SCHEMBL27608178 | 0.78 | BACE1 (0.41) | SLC6A4 | |
| SCHEMBL31458446 | 0.76 | ALDH1A1 (0.50) | ALDH1A1HTR3EHTR3BCYP1A2CYP3A4 | |
| SCHEMBL9319076 | 0.75 | ALDH1A1 (0.31) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3199969-A | — | — | None | — | — | JP | disclosed |
| CN-101239953-A | Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans | WYETH CORP (US) | 2008-08-13 | — | — | CN | disclosed |
| CN-100340562-C | Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans | WYETH CORP (US) | 2007-10-03 | — | — | CN | disclosed |
| CN-1681822-A | Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans | WYETH CORP (US) | 2005-10-12 | — | — | CN | disclosed |
| US-5120641-A | Incubating with sample, determining radioactivity | DAIICHI PURE CHEMICALS CO., LTD. (JP) | 1992-06-09 | — | — | US | disclosed |
| JP-H03199969-A | METHOD FOR MEASURING RETAKING PART OF SEROTONIN AND RADIO LIGAND USED IN THIS METHOD | DAI ICHI PURE CHEM CO LTD | 1991-08-30 | — | — | JP | disclosed |
| EP-0435192-A2 | Method for measurement of serotonin uptake sites and radioligand therefor | DAIICHI PURE CHEMICALS CO. LTD. (JP) | 1991-07-03 | — | — | EP | disclosed |