Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 3/20 | 0.71 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.55 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.55 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.55 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.55 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | JUN | P05412 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733214 | 1.00 | TBXAS1 (0.71) | TBXAS1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL10972590 | 0.91 | TBXAS1 (0.60) | TBXAS1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL8720944 | 0.91 | TBXAS1 (0.60) | TBXAS1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL14423635 | 0.88 | TBXAS1 (0.70) | TBXAS1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL9732451 | 0.84 | TBXAS1 (0.56) | TBXAS1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL9732453 | 0.84 | TBXAS1 (0.56) | TBXAS1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL5354515 | 0.83 | TBXAS1 (1.00) | TBXAS1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL5354522 | 0.83 | TBXAS1 (1.00) | TBXAS1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL6517314 | 0.82 | ALDH1A1 (0.48) | TBXAS1ALOX15LMNAJUNMAPT | |
| SCHEMBL22146948 | 0.82 | HDAC1 (0.52) | TBXAS1ALOX15LMNAFAAHHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153214-A | Treating cardiovascular disorders | CIBA-GEIGY CORPORATION (US) | 1992-10-06 | — | — | US | disclosed |
| US-5025025-A | Cardiovascular disorders | CIBA-GEIGY CORPORATION (US) | 1991-06-18 | — | — | US | disclosed |
| EP-0405391-A1 | Certain (arylsulfonamido- and pyridyl- or imidazolyl-)-substituted carboxylic acids and derivatives thereof | CIBA-GEIGY AG (CH) | 1991-01-02 | — | — | EP | disclosed |