Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733421 | 1.00 | MAPT (0.35) | MAPTALDH1A1PKMLMNATSHR | |
| SCHEMBL6638258 | 0.98 | ALDH1A1 (0.36) | MAPTALDH1A1PKMLMNATSHR | |
| SCHEMBL3046579 | 0.98 | ALDH1A1 (0.36) | MAPTALDH1A1PKMLMNATSHR | |
| SCHEMBL8465326 | 0.98 | ALDH1A1 (0.36) | MAPTALDH1A1PKMLMNATSHR | |
| SCHEMBL5567030 | 0.98 | ALDH1A1 (0.36) | MAPTALDH1A1PKMLMNATSHR | |
| SCHEMBL18150856 | 0.93 | SRD5A1 (0.37) | MAPTALDH1A1PKMLMNATSHR | |
| SCHEMBL9359669 | 0.93 | SRD5A1 (0.33) | ALDH1A1PKMLMNATSHRSRD5A1 | |
| SCHEMBL6675762 | 0.93 | SRD5A1 (0.33) | ALDH1A1PKMLMNATSHRSRD5A1 | |
| SCHEMBL432190 | 0.91 | MAPT (0.35) | MAPTALDH1A1PKMLMNATSHR | |
| SCHEMBL432189 | 0.91 | MAPT (0.35) | MAPTALDH1A1PKMLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5101039-A | Carboxyindoles, hypotensive agents, inhibitors of angiotensin converting enzyme | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-03-31 | — | — | US | disclosed |
| US-5008400-A | Chemical intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-04-16 | — | — | US | disclosed |
| US-4933361-A | HYPOTENSIVE AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-06-12 | — | — | US | disclosed |
| EP-0084164-B1 | DERIVATIVES OF BICYCLIC AMINO ACIDS, PROCESS FOR THEIR PREPARATION, AGENTS CONTAINING THEM AND THEIR USE, AS WELL AS BICYCLIC AMINO ACIDS AS INTERMEDIATES, AND PROCESS FOR PREPARING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-01-28 | — | — | EP | disclosed |
| EP-0084164-A2 | Derivatives of bicyclic amino acids, process for their preparation, agents containing them and their use, as well as bicyclic amino acids as intermediates, and process for preparing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-07-27 | — | — | EP | disclosed |