Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 13/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.36 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.36 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.36 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1572435 | 0.77 | KDM1A (0.44) | ABCB1CNR2DRD2DRD3ABCC9 | |
| SCHEMBL1573018 | 0.77 | CYP11B1 (0.49) | ABCB1CNR2ABCC9ABCC8KCNJ11 | |
| SCHEMBL1573172 | 0.77 | KDM1A (0.44) | ABCB1CNR2DRD2DRD3ABCC9 | |
| SCHEMBL9031297 | 0.77 | ABCB1 (0.41) | ABCB1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL9733795 | 0.77 | HTR2A (0.36) | DRD2LMNAKDM1A | |
| SCHEMBL1572481 | 0.77 | KDM1A (0.44) | ABCB1CNR2DRD2DRD3ABCC9 | |
| SCHEMBL9733609 | 0.74 | SIGMAR1 (0.38) | CYP2D6CYP2C19 | |
| SCHEMBL10563655 | 0.73 | CNR2 (0.42) | ABCB1CNR2ABCC9ABCC8KCNJ11 | |
| SCHEMBL10560531 | 0.73 | CNR2 (0.42) | ABCB1CNR2ABCC9ABCC8KCNJ11 | |
| SCHEMBL10560535 | 0.73 | CNR2 (0.42) | ABCB1CNR2ABCC9ABCC8KCNJ11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132307-A | TETRALIN COMPOUNDS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-21 | — | — | US | disclosed |
| EP-0368160-A1 | Tetralin derivatives | MERCK PATENT GmbH (DE) | 1990-05-16 | — | — | EP | disclosed |
| US-4800212-A | Pyrrolidone-2 compounds and anti-hypertensive use thereof | BEECHAM GROUP P.L.C. (GB) | 1989-01-24 | — | — | US | disclosed |
| EP-0168619-B1 | N-ACYLATED DI- OR TETRAHYDRONAPHTHALENAMINES, AND ANTIHYPERTENSIVE COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1988-08-24 | — | — | EP | disclosed |
| EP-0168619-A1 | N-acylated di- or tetrahydronaphthalenamines, and antihypertensive compositions containing them | BEECHAM GROUP PLC (GB) | 1986-01-22 | — | — | EP | disclosed |