Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.32 |
| ▸ | PNMT | P11086 | 2/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733609 | 0.78 | SIGMAR1 (0.38) | HTR2AALDH1A1TSHRADRA2AADRA2B | |
| SCHEMBL9733546 | 0.77 | ABCB1 (0.41) | LMNAKDM1ADRD2 | |
| SCHEMBL9240188 | 0.75 | KDM1A (0.40) | HTR2AHTR2CHTR2BOPRM1OPRD1 | |
| SCHEMBL29804038 | 0.75 | KDM1A (0.40) | HTR2AHTR2CHTR2BOPRM1OPRD1 | |
| SCHEMBL29122626 | 0.75 | HTR2A (0.39) | HTR2AHTR2CHTR2BOPRM1OPRD1 | |
| SCHEMBL27795745 | 0.71 | HTR2A (0.36) | HTR2AHTR2CHTR2BOPRM1OPRD1 | |
| SCHEMBL9141916 | 0.69 | HTR2A (0.36) | HTR2AHTR2CHTR2BADRA2AADRA2C | |
| SCHEMBL9733411 | 0.68 | OPRM1 (0.38) | HTR2AHTR2CHTR2BOPRM1OPRD1 | |
| SCHEMBL23361915 | 0.67 | CNR2 (0.41) | HTR2AHTR2CHTR2BOPRM1OPRD1 | |
| SCHEMBL9141090 | 0.67 | MEN1 (0.43) | HTR2AHTR2CHTR2BOPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132307-A | TETRALIN COMPOUNDS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-21 | — | — | US | disclosed |
| EP-0368160-A1 | Tetralin derivatives | MERCK PATENT GmbH (DE) | 1990-05-16 | — | — | EP | disclosed |