Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.31 |
| ▸ | MMP1 | P03956 | 2/20 | 0.31 |
| ▸ | MMP2 | P08253 | 2/20 | 0.31 |
| ▸ | MMP3 | P08254 | 2/20 | 0.31 |
| ▸ | MMP7 | P09237 | 2/20 | 0.31 |
| ▸ | MMP9 | P14780 | 2/20 | 0.31 |
| ▸ | MMP8 | P22894 | 2/20 | 0.31 |
| ▸ | MMP13 | P45452 | 2/20 | 0.31 |
| ▸ | MMP14 | P50281 | 2/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733714 | 1.00 | POLB (0.33) | POLBSLC6A2SLC6A4SLC6A3ADAM10 | |
| SCHEMBL1527326 | 0.86 | SMN1; SMN2 (0.34) | SLC6A2SLC6A4SLC6A3ADAM10MMP1 | |
| SCHEMBL13059971 | 0.86 | SLC6A2 (0.33) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1527328 | 0.86 | SMN1; SMN2 (0.34) | SLC6A2SLC6A4SLC6A3ADAM10MMP1 | |
| SCHEMBL9733830 | 0.83 | SMN1; SMN2 (0.34) | SLC6A2SLC6A4SLC6A3ADAM10MMP1 | |
| SCHEMBL13429355 | 0.83 | SLC6A2 (0.30) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3042987 | 0.83 | ADAM17 (0.38) | MMP2MMP9ADAM17 | |
| Hydrochloric Acid SCHEMBL3530197 | 0.83 | MMP1 (0.36) | MMP1MMP2MMP9ADAM17NPC1 | |
| SCHEMBL18806165 | 0.74 | — | — | |
| SCHEMBL7528133 | 0.74 | MMP1 (0.36) | MMP1MMP2MMP9ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166136-A | SPIROLACTAM CONTAINING PEPTIDES | GLAXO GROUP LIMITED (GB) | 1992-11-24 | — | — | US | disclosed |