Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | USP5 | P45974 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | MMP12 | P39900 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10691601 | 0.83 | ALDH1A1 (0.43) | KMT2AL3MBTL1CYP1A2LMNAALDH1A1 | |
| SCHEMBL20244667 | 0.78 | ALDH1A1 (0.53) | KMT2AL3MBTL1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL5717808 | 0.78 | KMT2A (0.63) | KMT2AUSP5NR4A2L3MBTL1CYP1A2 | |
| SCHEMBL10792559 | 0.77 | ALDH1A1 (0.46) | RAB9ASMN1; SMN2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL10884661 | 0.77 | NR4A2 (0.63) | KMT2AUSP5NR4A2L3MBTL1CYP1A2 | |
| SCHEMBL10353454 | 0.76 | NR4A2 (0.81) | KMT2AUSP5NR4A2L3MBTL1CYP1A2 | |
| SCHEMBL8165291 | 0.76 | ALDH1A1 (0.45) | L3MBTL1CYP1A2RAB9ASMN1; SMN2HIF1A | |
| SCHEMBL9711117 | 0.75 | HPGD (0.57) | KMT2AL3MBTL1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL6541372 | 0.75 | CA2 (0.47) | FFAR1LMNAHIF1AALDH1A1GAA | |
| SCHEMBL28861673 | 0.75 | HPGD (0.55) | KMT2AL3MBTL1LMNARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135940-A | Antiallegens, antiinflammatory agents | MERCK FROSST CANADA, INC. (CA) | 1992-08-04 | — | — | US | disclosed |
| US-4876246-A | Benzo[a]phenothiazines and hydro-derivatives for inhibiting leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1989-10-24 | — | — | US | disclosed |
| EP-0252639-A1 | Leukotriene antagonists | MERCK FROSST CANADA INC. (CA) | 1988-01-13 | — | — | EP | disclosed |
| EP-0104885-B1 | LEUKOTRIENE ANTAGONISTS, THEIR PRODUCTION, AND COMPOSITIONS CONTAINING THEM | MERCK FROSST CANADA INC. (CA) | 1986-06-04 | — | — | EP | disclosed |
| EP-0156233-A2 | Use of leukotriene antagonists for producing cytoprotective pharmaceutical compositions and process for producing cytoprotective pharmaceutical compositions | MERCK & CO. INC. (US) | 1985-10-02 | — | — | EP | disclosed |
| EP-0104885-A1 | Leukotriene antagonists, their production, and compositions containing them | MERCK FROSST CANADA INC. (CA) | 1984-04-04 | — | — | EP | disclosed |