Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.44 |
| ▸ | KDM5C | P41229 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13940646 | 0.89 | KMT2A (0.45) | TMEM97ALDH1A1KDM4ECXCR4TSHR | |
| SCHEMBL7498479 | 0.85 | DRD4 (0.59) | ALDH1A1KDM4ETSHRMAPTDRD2 | |
| SCHEMBL30484462 | 0.84 | EGLN1 (0.47) | ALDH1A1KDM4ETSHRMAPTMAPK1 | |
| SCHEMBL29204511 | 0.84 | EGLN1 (0.46) | ALDH1A1KDM4ETSHRMAPTMAPK1 | |
| SCHEMBL7500264 | 0.84 | ALDH1A1 (0.66) | ALDH1A1KDM4EHSD17B10TSHRDRD2 | |
| SCHEMBL30484482 | 0.83 | EGLN1 (0.46) | ALDH1A1KDM4ETSHRMAPTMAPK1 | |
| SCHEMBL10375167 | 0.83 | TRPV6 (0.53) | ALDH1A1KDM4ESIGMAR1DRD2DRD4 | |
| SCHEMBL29204494 | 0.83 | HRH3 (0.51) | ALDH1A1KDM4ETSHRMAPTMAPK1 | |
| SCHEMBL29204460 | 0.83 | EGLN1 (0.48) | ALDH1A1KDM4ETSHRMAPTMAPK1 | |
| SCHEMBL29204466 | 0.83 | EGLN1 (0.48) | ALDH1A1KDM4ETSHRMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114945-A | Spiropiperidine derivatives | GLAXO GROUP LIMITED (GB) | 1992-05-19 | — | — | US | disclosed |
| EP-0330461-A2 | Piperidine derivatives | GLAXO GROUP LIMITED (GB) | 1989-08-30 | — | — | EP | disclosed |