SCHEMBL9734674

SCHEMBL9734674

O[C@@]1(c2cccs2)CCCC[C@H]1n1cncn1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM3 P20309 2/20 0.42
CHRM2 P08172 1/20 0.42
CHRM4 P08173 1/20 0.42
CHRM5 P08912 1/20 0.42
CHRM1 P11229 1/20 0.42
KMT2A Q03164 2/20 0.42
MEN1 O00255 1/20 0.42
PRCP P42785 1/20 0.42
SIGMAR1 Q99720 1/20 0.42
SLC6A2 P23975 1/20 0.34
SLC6A3 Q01959 1/20 0.33
OPRM1 P35372 3/20 0.32
OPRL1 P41146 2/20 0.32
OPRD1 P41143 1/20 0.32
OPRK1 P41145 1/20 0.32
SLC6A9 P48067 5/20 0.32
SLC6A4 P31645 1/20 0.32
CYP17A1 P05093 1/20 0.31
HDAC3 O15379 1/20 0.30
HDAC1 Q13547 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9734678 1.00 CHRM3 (0.42) CHRM3CHRM2CHRM4CHRM5CHRM1
SCHEMBL9734681 1.00 CHRM3 (0.42) CHRM3CHRM2CHRM4CHRM5CHRM1
SCHEMBL9733939 0.99 KMT2A (0.44) CHRM3CHRM2CHRM4CHRM5CHRM1
SCHEMBL9733936 0.99 KMT2A (0.44) CHRM3CHRM2CHRM4CHRM5CHRM1
SCHEMBL9733948 0.99 KMT2A (0.44) CHRM3CHRM2CHRM4CHRM5CHRM1
SCHEMBL15834041 0.79 SLC6A9 (0.43) OPRM1OPRL1SLC6A9
SCHEMBL9734637 0.79 IDO1 (0.30) CYP17A1
SCHEMBL9736578 0.79 IDO1 (0.30) CYP17A1
SCHEMBL9734640 0.79 IDO1 (0.30) CYP17A1
SCHEMBL9734636 0.79 IDO1 (0.30) CYP17A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5091539-A Reacting an ozolyl cycloalkanone with Grignard reagent or alkali metal compound SHIONOGI & CO., LTD. (JP) 1992-02-25 US disclosed
EP-0152031-A2 Azolyl cycloalkanol derivatives and agricultural fungicides SHIONOGI & CO., LTD. (JP) 1985-08-21 EP disclosed