SCHEMBL9734749

SCHEMBL9734749

CCCn1c(=O)[nH]c(=O)c2c(-c3ccc(F)cc3)c(C=O)c(C(C)C)nc21

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.44
ALDH1A1 P00352 3/20 0.44
RXFP1 Q9HBX9 2/20 0.44
MAPK1 P28482 1/20 0.44
KDM1A O60341 2/20 0.41
IDO1 P14902 1/20 0.41
ADORA2A P29274 5/20 0.40
ADORA2B P29275 4/20 0.40
GCGR P47871 4/20 0.39
PDE4A P27815 2/20 0.36
PDE4B Q07343 2/20 0.36
PDE4C Q08493 2/20 0.36
PDE4D Q08499 2/20 0.36
ADORA3 P0DMS8 1/20 0.36
HPGD P15428 1/20 0.36
ADORA1 P30542 1/20 0.36
BLM P54132 1/20 0.36
PDE3A Q14432 1/20 0.36
HSD17B10 Q99714 1/20 0.36
HTT P42858 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9383396 0.94 KDM4E (0.48) KDM4EALDH1A1RXFP1MAPK1ADORA2A
SCHEMBL9736194 0.92 GCGR (0.40) KDM4EALDH1A1RXFP1MAPK1ADORA2A
SCHEMBL9382065 0.87 GCGR (0.41) KDM4EALDH1A1RXFP1MAPK1GCGR
SCHEMBL9383734 0.87 GCGR (0.40) ALDH1A1KDM1AIDO1GCGRHPGD
SCHEMBL9388048 0.85 KDM4E (0.45) KDM4EALDH1A1RXFP1MAPK1ADORA2A
SCHEMBL9736896 0.85 KDM4E (0.45) KDM4EALDH1A1RXFP1MAPK1ADORA2A
SCHEMBL9384186 0.83 GCGR (0.38) KDM4EALDH1A1RXFP1MAPK1GCGR
SCHEMBL9735137 0.83 GCGR (0.38) KDM4EALDH1A1RXFP1MAPK1GCGR
SCHEMBL9387249 0.79 GCGR (0.54) KDM4EALDH1A1GCGRHTT
SCHEMBL9736123 0.77 GCGR (0.37) ALDH1A1KDM1AIDO1GCGRTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5145959-A Enzyme inhibitors; antilipemic agents; treatment of atherosclerosis BAYER AKTIENGESELLSCHAFT (DE) 1992-09-08 US claimed