Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 5/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | TPH1 | P17752 | 2/20 | 0.35 |
| ▸ | TPH2 | Q8IWU9 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HMGCR | P04035 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9384186 | 1.00 | GCGR (0.38) | GCGRRXFP1TPH1TPH2KDM4E | |
| SCHEMBL9388048 | 0.91 | KDM4E (0.45) | GCGRRXFP1KDM4EMAPK1ALDH1A1 | |
| SCHEMBL9736896 | 0.91 | KDM4E (0.45) | GCGRRXFP1KDM4EMAPK1ALDH1A1 | |
| SCHEMBL9736194 | 0.90 | GCGR (0.40) | GCGRRXFP1TPH1TPH2KDM4E | |
| SCHEMBL9736133 | 0.87 | GCGR (0.37) | GCGRALDH1A1TP53 | |
| SCHEMBL9736123 | 0.87 | GCGR (0.37) | GCGRALDH1A1TP53 | |
| SCHEMBL9736090 | 0.84 | RXRA (0.40) | RXFP1TPH1TPH2KDM4EMAPK1 | |
| SCHEMBL9384462 | 0.84 | RXRA (0.40) | RXFP1TPH1TPH2KDM4EMAPK1 | |
| SCHEMBL9734648 | 0.83 | DPP4 (0.42) | GCGRMAPK1HMGCRESR1CHRM1 | |
| SCHEMBL9387195 | 0.83 | DPP4 (0.42) | GCGRMAPK1HMGCRESR1CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5145959-A | Enzyme inhibitors; antilipemic agents; treatment of atherosclerosis | BAYER AKTIENGESELLSCHAFT (DE) | 1992-09-08 | — | — | US | disclosed |
| US-5075311-A | Anticholesterol agents | BAYER AKTIENGESELLSCHAFT (DE) | 1991-12-24 | — | — | US | disclosed |