Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 4/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | PDE6D | O43924 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.38 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9735125 | 1.00 | HMGCR (0.49) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL9387121 | 0.92 | HMGCR (0.47) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL9735282 | 0.84 | HMGCR (0.57) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL9734698 | 0.81 | HMGCR (0.43) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL9734676 | 0.81 | HMGCR (0.43) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL9482432 | 0.79 | HMGCR (0.56) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL9482422 | 0.79 | HMGCR (0.56) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL9735571 | 0.79 | GCGR (0.39) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL9383069 | 0.79 | GCGR (0.39) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL9382441 | 0.78 | GCGR (0.42) | HMGCRALDH1A1GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5145959-A | Enzyme inhibitors; antilipemic agents; treatment of atherosclerosis | BAYER AKTIENGESELLSCHAFT (DE) | 1992-09-08 | — | — | US | disclosed |
| US-5075311-A | Anticholesterol agents | BAYER AKTIENGESELLSCHAFT (DE) | 1991-12-24 | — | — | US | disclosed |