Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.44 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9734223 | 0.76 | HRH3 (0.50) | HRH3CYP3A4LMNAMEN1USP2 | |
| SCHEMBL20152074 | 0.76 | TDP1 (0.56) | CYP3A4LMNAMEN1USP2ALDH1A1 | |
| SCHEMBL16933991 | 0.75 | LMNA (0.62) | HRH3CYP3A4LMNAMEN1USP2 | |
| SCHEMBL1696516 | 0.75 | ALDH1A1 (0.59) | HRH3CYP3A4LMNAMEN1USP2 | |
| Hydrochloric Acid SCHEMBL9735319 | 0.75 | ACACB (0.52) | CYP3A4LMNAMEN1USP2ALDH1A1 | |
| SCHEMBL9733079 | 0.75 | HRH3 (0.59) | HRH3CYP3A4LMNAMEN1USP2 | |
| Hydrochloric Acid SCHEMBL9735329 | 0.75 | SLC2A1 (0.54) | CYP3A4LMNAMEN1USP2ALDH1A1 | |
| SCHEMBL9734066 | 0.75 | SLC2A1 (0.54) | CYP3A4LMNAMEN1USP2ALDH1A1 | |
| SCHEMBL9735604 | 0.75 | SLC2A1 (0.54) | CYP3A4LMNAMEN1USP2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9734547 | 0.75 | HRH3 (0.49) | HRH3CYP3A4LMNAMEN1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135955-A | Anticoagulants or antifungal activity | ELI LILLY AND COMPANY (US) | 1992-08-04 | — | — | US | disclosed |
| EP-0339878-A2 | Propanamine derivatives | ELI LILLY AND COMPANY (US) | 1989-11-02 | — | — | EP | disclosed |