Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 8/20 | 0.76 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.76 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.76 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.76 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.76 |
| ▸ | LMNA | P02545 | 1/20 | 0.76 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 10/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levcromakalim SCHEMBL30059152 | 0.87 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| (-)-Cromakalim SCHEMBL3771007 | 0.87 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| Cromakalim SCHEMBL30110320 | 0.87 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| (-)-Cromakalim SCHEMBL24658941 | 0.87 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| Cromakalim SCHEMBL3312760 | 0.87 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| (-)-Cromakalim SCHEMBL25029865 | 0.87 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| (-)-Cromakalim SCHEMBL10644663 | 0.87 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| (-)-Cromakalim SCHEMBL29345689 | 0.87 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| (-)-Cromakalim SCHEMBL12833 | 0.87 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| Levcromakalim SCHEMBL122344 | 0.87 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130322-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-14 | — | — | US | disclosed |
| EP-0415065-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |