Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.47 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.47 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.47 |
| ▸ | DHFR | P00374 | 2/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.43 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30301439 | 0.86 | MEN1 (0.62) | MEN1POLBMAPK1KMT2ACHRNB4 | |
| SCHEMBL3794904 | 0.86 | MEN1 (0.62) | MEN1POLBMAPK1KMT2ACHRNB4 | |
| SCHEMBL29463389 | 0.82 | ALOX5 (0.62) | MEN1POLBMAPK1KMT2AMAOA | |
| SCHEMBL707702 | 0.82 | ALOX5 (0.62) | MEN1POLBMAPK1KMT2AMAOA | |
| SCHEMBL3790084 | 0.80 | MAPK1 (0.62) | MEN1POLBMAPK1KMT2ACHRNB4 | |
| SCHEMBL30961597 | 0.79 | MEN1 (0.63) | MEN1POLBMAPK1KMT2AMAOA | |
| SCHEMBL29275171 | 0.79 | MEN1 (0.63) | MEN1POLBMAPK1KMT2AMAOA | |
| Hexane SCHEMBL27537617 | 0.77 | ALOX5 (0.53) | MEN1KMT2AMAOANPC1RAB9A | |
| SCHEMBL31464043 | 0.76 | POLB (0.68) | MEN1POLBMAPK1KMT2AMAOA | |
| SCHEMBL18640278 | 0.76 | POLB (0.68) | MEN1POLBMAPK1KMT2AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5126125-A | Decreasing the melanin content in mammalian skin and hair using 5,6-dihydroxindole derivatives | YALE UNIVERSITY (US) | 1992-06-30 | — | — | US | disclosed |