Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.59 |
| ▸ | LTA4H | P09960 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9736398 | 0.80 | DYRK1A (0.69) | DYRK1ALTA4HALDH1A1KMT2AMKNK1 | |
| SCHEMBL1143140 | 0.74 | DYRK1A (1.00) | DYRK1ALTA4HALDH1A1KMT2AMKNK1 | |
| Hydrochloric Acid SCHEMBL3260970 | 0.73 | DYRK1A (0.97) | DYRK1ALTA4HALDH1A1KMT2AMKNK1 | |
| SCHEMBL472165 | 0.73 | CA12 (0.57) | ALDH1A1KMT2AMEN1USP2SMN1; SMN2 | |
| SCHEMBL9065504 | 0.73 | CA12 (0.57) | ALDH1A1KMT2AMEN1USP2SMN1; SMN2 | |
| SCHEMBL1396265 | 0.73 | CDK1 (0.36) | DYRK1AALDH1A1KMT2AMKNK1MKNK2 | |
| SCHEMBL2303414 | 0.72 | ALDH1A1 (0.67) | DYRK1ALTA4HALDH1A1KMT2AMKNK1 | |
| SCHEMBL20554521 | 0.72 | CA12 (0.53) | ALDH1A1KMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL6962038 | 0.72 | DYRK1A (0.71) | DYRK1ALTA4HALDH1A1KMT2AMKNK1 | |
| SCHEMBL28573902 | 0.71 | ALDH1A1 (0.71) | DYRK1ALTA4HALDH1A1KMT2AMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132424-A | Anticholesterol, treatment of atherosclerosis | THE UPJOHN COMPANY (US) | 1992-07-21 | — | — | US | disclosed |
| EP-0425541-A1 | PYRAZOLO-AZOLO-PYRIMIDINE-DIONES | THE UPJOHN COMPANY (US) | 1991-05-08 | — | — | EP | disclosed |
| WO-1990001031-A1 | PYRAZOLO-PYRROLO-PYRIMIDINE-DIONES | THE UPJOHN COMPANY (US) | 1990-02-08 | — | — | WO | disclosed |