Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.61 |
| ▸ | GAA | P10253 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | LTA4H | P09960 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.56 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 4/20 | 0.55 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1143140 | 0.81 | DYRK1A (1.00) | DYRK1AHSD17B10GAAMAPTNPC1 | |
| SCHEMBL9735684 | 0.80 | DYRK1A (0.59) | DYRK1AHSD17B10GAAMAPTNPC1 | |
| Hydrochloric Acid SCHEMBL3260970 | 0.80 | DYRK1A (0.97) | DYRK1AHSD17B10GAAMAPTNPC1 | |
| SCHEMBL6962038 | 0.79 | DYRK1A (0.71) | DYRK1AHSD17B10GAAMAPTNPC1 | |
| SCHEMBL12511618 | 0.78 | DYRK1A (0.56) | DYRK1AHSD17B10GAAMAPTNPC1 | |
| SCHEMBL1662946 | 0.75 | SMN1; SMN2 (1.00) | DYRK1AHSD17B10GAAMAPTNPC1 | |
| SCHEMBL14190747 | 0.75 | LTA4H (0.74) | DYRK1AHSD17B10MAPTNPC1RAB9A | |
| SCHEMBL28573902 | 0.75 | ALDH1A1 (0.71) | DYRK1AHSD17B10GAAMAPTNPC1 | |
| SCHEMBL31660140 | 0.75 | MAPT (0.54) | GAAMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL26093604 | 0.75 | MAPT (0.54) | GAAMAPTNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112876482-B | Polysubstituted heterocyclic derivative, preparation method and medical application thereof | 中国药科大学 | 2023-07-28 | — | — | CN | disclosed |
| CN-112876482-A | Polysubstituted heterocyclic derivative, preparation method and medical application thereof | 中国药科大学 | 2021-06-01 | — | — | CN | disclosed |
| US-5132424-A | Anticholesterol, treatment of atherosclerosis | THE UPJOHN COMPANY (US) | 1992-07-21 | — | — | US | disclosed |
| EP-0425541-A1 | PYRAZOLO-AZOLO-PYRIMIDINE-DIONES | THE UPJOHN COMPANY (US) | 1991-05-08 | — | — | EP | disclosed |
| WO-1990001031-A1 | PYRAZOLO-PYRROLO-PYRIMIDINE-DIONES | THE UPJOHN COMPANY (US) | 1990-02-08 | — | — | WO | disclosed |